摘要
目的:探讨O型血孕妇新生儿溶血病(HDN)的发生情况及影响因素。方法:选择2013年6月~2016年12月在海南省人民医院行产前检查的140例O型血孕妇,进行产前血型抗体效价检测,比较丈夫ABO血型、产前IgG抗-A(B)效价及新生儿性别与HDN的发生情况。结果:O型血孕妇产后HDN的总发生率为37.9%。丈夫不同ABO血型、男性和女性新生儿HDN的发生率比较差异均无统计学意义(P>0.05)。产前IgG抗-A(B)效价≤32、64、128、256和≥512组HDN的发生率分别为9%、27%、60%、75%、90%,组间比较差异均有统计学意义(P<0.05),且随着抗体效价的增加,HDN的发生率逐渐升高。结论:O型血孕妇HDN的发生率较高,与丈夫ABO血型和新生儿性别均无关,与孕妇产前血清IgG抗-A(B)效价有关,随抗体效价增高而升高。
Objectve： To investigate the incidence of hemolytic disease of newborn in O-type blood puerpera and its influencing factors. Methods： 140 cases of O-type blood puerperal who performed prenatal examination in our hospital from June 2013 to December2016 were selected, the prenatal IgG Anti-A or Anti-B titer levels of puerpera were screened, the incidence of HDN were compared between husbands with different ABO groups, gravida with different prenatal IgG anti-A（B） titer and newborns with different gender. Results： The total incidence of HDN in O-type blood puerperal was 37.9%. No significance was found in the incidence of HDN between husbands with different ABO groups and newborns with different gender（P〉0.05）. The incidence of HDN in prenatal IgG Anti-A or Anti-B titer levels≤32, 64, 128, 256 and ≥512 group were 9%, 27%, 60%, 75%, 90%（P〈0.05）, The incidence of HDN was increased with the elevation of prenatal IgG Anti-A or Anti-B titer levels. Conclusion： The incidence of HDN in O-type blood puerperal was high, it had no correlation with the ABO group of husband and gender of newborns, but was significantly and positively related to the increase of IgG Anti-A or Anti-B titer levels.
作者
符小玲
蔡兴权
夏兰
吴巨峰
FU Xiao-ling;CAI Xing-quan;XIA Lan：;WU Ju-feng(Department of blood transfusion of Hainan maternal and child health hospital,Haikou,Hainan,570311,China;Department of blood transfusion of People＇s Hospital of Hainan Province,Haikou,Hainan,570311,China)
出处
《现代生物医学进展》
CAS
2018年第15期2970-2972,共3页
Progress in Modern Biomedicine
