摘要
目的探讨血清同型半胱氨酸(HCY)与头颈部动脉粥样硬化关系。方法选择2016年1月至2016年12月合肥市第二人民医院行头颈部CT血管造影术(CTA)明确有动脉粥样硬化病变患者119例,根据头颈部动脉CTA结果,将轻度及轻度以上狭窄的106例患者纳为试验组,将无动脉狭窄的13例患者纳为对照组,比较两组患者的血清HCY水平。再根据头颈部动脉狭窄程度,分为轻度狭窄组(28例)、中度狭窄组(29例)与重度狭窄组(49例),比较3组患者血清HCY水平。结果试验组患者血清HCY水平为(17. 76±15. 14)μmol/L,对照组为(10. 95±2. 73)μmol/L,两组差异有统计学意义(P <0. 05)。轻度狭窄组血清HCY水平(12. 77±8. 05)μmmol/L,中度狭窄组为(16. 01±8. 39)μmmol/L,重度狭窄组为(22. 20±20. 29)μmmol/L,重度狭窄组与中度狭窄组、轻度狭窄组的血清HCY水平比较,差异有统计学意义(P <0. 05)。结论 HCY在头颈动脉粥样硬化中起着一定作用,HCY对头颈部动脉粥样硬化的作用机制及长期影响有待深入研究。
Objective To investigate the correlation between serum homocysteine （ HCY） and atherosclerosis of head and neck. Methods A total of 119 cases of atherosclerosis confirmed by head and neck CT angiography from Jan to Dec 2016 in the Second People＊ s Hospital of Hefei were selectedand divided into twogroups, and 106 patients with stenosis of the head and neck artery were considered as ex-perimental group, another 13 patients with no artery stenosis as control group, then the HCY levels between two groupswere compeired. Ac-cording to the degree of stenosis of head and neck artery, there were 28 cases in mild stenosis, 29 in moderate stenosis group and 49 in severe stenosis group. The level of HCY was compared between the three groups. Results The serum HCY level in experimental group was（ 17.76 ± 15.14） jxmol/L and incontrol group was（10. 95 ± 2. 73） [xmol/L. The HCY value of the experimental group was significantly different fromthe control groupCPcO.05）. HCYlevel in mild,moderate and severestenosis groupwas（12.77±8.05）[immol/L, （ 1 6 .01 ± 8 .3 9 ） jxmmol/L,and（22.20 ± 20.29） （xmmol/L, respectively. The difference between severe and moderate stenosis group was statistically signifi- cant（P〈0.05） , and thatbetween severe and mild stenosis group was also statistically significant（P 〈 0. 05）. Conclusion HCY plays a role in atherosclerosis of the head and neck. The mechanism and long - term effects of HCY on head and neck atherosclerosis need to be fur-ther studied.
作者
陈良
戴元昶
CHEN Liang;DAI Yuanchang(Department of Hyperbaric Oxygen,the Second People＇s Hospital of Hefei 9Hefei23001l,China)
出处
《安徽医学》
2018年第9期1079-1082,共4页
Anhui Medical Journal
