摘要
目的探讨人脐带间充质干细胞(hUC-MSCs)治疗心脏扩大伴心力衰竭类心肌病病儿的效果。方法心脏扩大伴心力衰竭类心肌病病儿17例,均接受hUC-MSCs治疗,分析治疗前后临床症状、体征及辅助检查结果。主要观察指标为病儿心力衰竭的症状,无症状生存时间,死亡和存活人数及左心室射血分数、左心室短轴缩短率,左心室舒张末期内径、左心室收缩末期内径和氨基末端脑钠肽前体(NT-proBNP)水平。结果 hUC-MSCs治疗后,17例病儿临床症状明显改善,活动耐力增强,13例(76.5%)病儿无症状生存;治疗后病儿左心室射血分数明显提高(P<0.05),NT-proBNP水平不同程度降低;15例(88.2%)病儿心功能不同程度好转或无恶化。细胞治疗后原发心律失常不同程度改善,生存质量改善,无死亡者。结论 hUC-MSCs治疗可改善心脏扩大伴心力衰竭的心肌病病儿的临床症状及心功能,改善生存质量。
Objective To investigate the clinical effect of human umbilical cord mesenchymal stem cells（hUC-MSCs）in the treatment of cardiomyopathy with cardiomegaly and heart failure in children. Methods A total of 17 children with cardiomyopathy with cardiomegaly and heart failure were enrolled and were given the treatment with hUC-MSCs.Clinical symptoms,signs,and auxiliary examination results before and after treatment were analyzed.Major observation indices included clinical symptoms of heart failure,symptom-free survival time,numbers of deaths and survivors,left ventricular ejection fraction,left ventricular fractional shortening,left ventricular end-diastolic diameter,left ventricular end-systolic diameter,and N-terminal pro-brain natriuretic peptide（NT-proBNP）level. Results After the treatment with hUC-MSCs,all 17 children had significant improvements in clinical symptoms and activity endurance,and 13 children（76.5%）achieved symptom-free survival.After treatment,the children had a significant increase in left ventricular ejection fraction（P〈0.05）and varying degrees of reduction in NT-proBNP level（P〈0.05）.Of all children,15（88.2%）had varying degrees of improvement in cardiac function or had no deterioration.There were varying degrees of improvement in primary arrhythmia and a significant improvement in quality of life.No deaths were observed.Conclusion The treatment with hUC-MSCs can improve the clinical symptoms and cardiac function of children with cardiomyopathy with cardiomegaly and heart failure and improve their quality of life.
作者
张钰
王本臻
纪志娴
万浩
李自普
ZHANG Yu;WANG Benzhen;JI Zhixian;WAN Hao;LI Zipu(Heart Center,Women and Children＇s Hospital of Qingdao University,Qingdao 266034,China)
出处
《精准医学杂志》
2018年第4期295-299,共5页
Journal of Precision Medicine
基金
青岛市医疗卫生优秀人才培养项目资助(青卫科教字[2017]4号)
关键词
间充质基质细胞
脐带
心肌病
扩张型
心力衰竭
心脏功能试验
Mesenchymal stromal cells
Umbilical cord
Cardiomyopathy
dilated
Heart failure
Heart function tests
