摘要
目的观察三氧化二砷(ATO)联合全反式维甲酸(ATRA)治疗初治急性早幼粒细胞白血病(APL)的疗效及对患者生活质量的影响。方法回顾性分析92例初治APL患者的临床资料,根据治疗方法不同将患者分为对照组及观察组各46例,对照组予ATRA治疗,观察组予ATO联合ATRA治疗。比较两组诱导治疗阶段达到完全缓解(CR)所需时间,维甲酸受体α(PML-RARα)融合基因转阴率,新鲜冷冻血浆、血小板输注总量及不良反应,采用EORTC QLQ-C30量表评价患者的生活质量。结果观察组诱导期间达到CR所需时间为(27.6±5.3)d,输注血浆及血小板总量分别为(830.2±75.3)ml和(33.1±8.8)U,PML-RARα转阴率为100%,与对照组的(33.8±6.6)d、(942.8±67.6)ml、(52.3±12.8)U和82.6%比较,差异均有统计学意义(P﹤0.05)。观察组患者诱导后EORTC QLQ-C30量表中总体健康状况更优,差异有统计学意义(P﹤0.05)。两组患者不良反应发生率比较,差异无统计学意义(P﹥0.05)。结论 ATO联合ATRA治疗初治APL安全有效,且可明显改善患者生活质量,值得临床推广应用。
Objective To observe the curative effect of arsenic trioxide （ATO） combined with all-trans retinoic acid （ATRA） for newly diagnosed acute promyelocytic leukemia （APL）, and its impact on quality of life. Method 92 patients with APL were included in the analysis, and were stratified as control group or study group by respective treatment regi- mens, with 46 cases in each, the control group received ATRA, while the study group was given ATO and ATRA. The time to complete response （CR） during induction period, the negative rate of promyelocytic leukemia retinoic acid recep- tor α （PML-RARa）, the volume of fresh frozen plasma and PLT transfusion, and adverse reactions were compared be- tween the two groups. The quality of life was evaluated by EORTC QLQ-C30. Result For study group, during the induc- tion period, the time to CR was （27.6±5.3） d, the volume of fresh frozen plasma and PLT transfusion was （830.2±75.3） ml and （33.1±8.8） U, the negative rate of PML-RARa was 100%, all were better than those in control group at （33.8±6.6） d, （942.8±67.6） ml, （52.3±12.8） U and 82.6% （P〈0.05）. The score of general health evaluated using EORTC QLQ-C30 was higher in study group than that in control group （P〈0.05）. The incidence of adverse reactions was similar in both groups （P〉0.05）. Conclusion ATO combined with ATRA is effective and safe for newly diagnosed APL, and could improve quality of life, so is worthy of widely clinical use.
作者
苏伊拉
吕爱娥
骈晓琴
高大
SU Yila;LYU Aie;PlAN Xiaoqin;GAO Da(Department of Hematology,Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,Inner Mongolia,China;Department of Medicine,New District Hospital of Hohhot,Hohhot 010000,Inner Mongolia,China)
出处
《癌症进展》
2018年第8期998-1000,共3页
Oncology Progress
关键词
三氧化二砷
全反式维甲酸
急性早幼粒细胞白血病
疗效
生活质量
arsenic trioxide
all-trans retinoic acid
acute promyelocytic leukemia
clinical effect
quality of life
