摘要
目的探讨三氧化二砷治疗急性早幼粒细胞白血病化疗所引起的血清血脂变化、不良反应。方法从2005年4月~2015年3月本院内科收治的白血病患者中选出64例急性早幼粒细胞白血病者,分析其在化疗中联合应用三氧化二砷治疗后血清总胆固醇(TC)、血清三酰甘油(TG)的变化及出现的不良反应和生存率和复发率。结果治疗3个疗程,患者TC和TG指标均呈逐渐升高趋势,差异有统计学意义(P<0.05)。不良反应以消化系统反应为主,骨髓抑制和肝肾功能损害最为严重。其治疗后6、12、18个月的生存率分别为96.77%、91.94%、85.48%,复发率分别为9.68%、6.45%、4.84%。结论三氧化二砷和化疗联合治疗急性早幼粒细胞白血病血清血脂升高,不良反应类型繁多。
Objective To study the changes of serum lipids and adverse reaction triggered by Arsenic Trioxide in acute promyelocytic leukemia with the combination of chemotherapy.Methods A total of 64 patients with acute promyelocytic leukemia in our department of internal medicine in our hospital from April 2005 to March 2015 were selected.The levels of serum total cholesterol（TC） and triacylglycerol（TG）,adverse reactions,survival rate and recurrence rate were analyzed during combination of Arsenic Trioxide and chemotherapy.Results After 3 courses of treatment,the indexes of TC and TG were both displayed increasing tendency with statistical differences（P〈0.05）.The adverse reaction was mainly occurred in digestive system,and the most serious adverse reactions were bone marrow suppression and damages on the functions of liver and kidney.The survival rates 6,12,18 months after treatment was 96.77%,91.94%,85.48% respectively,the recurrence rate 6,12,18 months after treatment was 9.68%,6.45%,4.84% respectively.Conclusion In the clinical treatment of acute promyelocytic leukemia,combination of Arsenic Trioxide and chemotherapy will lead to the increase of serum lipids as well as many types of adverse reactions.
出处
《中国当代医药》
2017年第8期34-36,共3页
China Modern Medicine
关键词
三氧化二砷
化疗
白血病
血清血脂
不良反应
Arsenic Trioxide
Chemotherapy
Leukemia
Serum lipids
Adverse reactions
