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预防性鞘内注射化疗在急性早幼粒细胞白血病中的疗效 被引量:6

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摘要 目的探讨预防性鞘内注射化疗在急性早幼粒细胞性白血病(APL)患者临床疗效。方法回顾性分析20例预防性鞘注APL缓解患者(鞘注组),与同期未行鞘注治疗27例患者作对照(非鞘注组)。随访中位时间30(6~62)个月。比较两组发生中枢神经系统白血病(CNSL)及复发率。结果鞘注组20例无一例复发,其中鞘注组中3例高危患者CR后首次腰穿检查发现无症状单纯脑脊液压力增高,鞘注治疗后恢复正常,均随访3年以上未发生CNSL。非鞘注组27例4例复发(1例中危,3例高危),其中1例高危患者发生CNSL。结论预防性鞘内注射化疗有益于减少APL患者CNSL发生,可能有助于减少白血病复发。
出处 《广东医学》 CAS CSCD 北大核心 2012年第19期2943-2945,共3页 Guangdong Medical Journal
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  • 1张之南.血液病诊断及疗效标准[M].3版.北京:科学出版社,2008:1. 被引量:83
  • 2SANZ M A, LO COCO F, MARTIN G, et al. Definition of relapse risk and role of non - anthracycline drugs for consolidation in patients with acute promyelocytic leukemia : a joint study of the PET- HEMA and GIMEMA cooperative groups [ J ]. Blood, 2000, 96 (4) : 1247 -1253. 被引量:1
  • 3LO COCO F, AVVISATI G, VIGNETTI M, et al. Front -linc treatment of acute promyelocytic leukemia with AIDA induction followed by risk - adapted consolidation for adults patients younger than 61 years: results of the AIDA -2000 trail of the GIMEMA Group[J]. Blood, 2010, 116(17): 3171 -3179. 被引量:1
  • 4NAGAI S, NANNYA Y, ARAI S, et al. Molecular or cytogenetic monitoring and preemptive therapy for central nervous system relapse of acute promyelocytic leukemia [ J ]. Haematologica, 2010, 95(1) : 169 -171. 被引量:1
  • 5HOUSMAN E, CHANG P, LANE S W, et al. CNS relapse in acute promyeloctyic leukemia[ J ]. J Clin Oncol, 2010, 28 (24) : e409 - e411. 被引量:1
  • 6VEGA RUIZ A, FADERL S, ESTROV Z, et al. Incidence of extramedullary disease in patients with acute pmmyelocytic leukemia: a single - institution experience [ J ]. Int J Hematol, 2009, 89 (4) : 489 -496. 被引量:1
  • 7DE BOTTON S, SANZ M A, CHEVRET S, et al. Extramedullary relapse in acute promyelocytic leukemia treated with all -trans retinoic acid and chemotherapy[J]. Leukemia, 2006, 20(1): 35 -41. 被引量:1
  • 8MONTESINOS P, DiAZ MEDIAVILLA J, DEBeN G, et al. Central nervous system involvement at first relapse in patients with acute promyelocytic leukemia treated with all - trans retinoie acid and anthracycline monochemotherapy without intrathecal prophylaxis[J]. Haematologica, 2009, 94(9): 1242-1249. 被引量:1
  • 9ADIOS L, CHEVRET S, RAFFOUX E, et al. Is cytarabine useful in the treatment of acute promyelocytic leukemia? Results of a randomized trial from the European Acute Promyelocytic Leukemia Group[J]. J Clin Oncol, 2006, 24(36) : 5703 -5710. 被引量:1
  • 10华海应,高华强,陈珏.急性早幼粒细胞性白血病并发中枢神经系统白血病的临床研究[J].南通大学学报(医学版),2009,29(2):118-119. 被引量:6

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