摘要
目的分析血清低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)、核转录因子(nuclear transcription factor kappa B,NF-κB)、白细胞介素-6(interleukin-6,IL-6)水平变化与冠心病患者膜联蛋白A1(annexin A1)的相关性。方法选取本院确诊的冠心病患者80例纳入研究,对血清LDL-C、NK-κB、IL-6水平变化与冠心病患者annexin A1的相关性进行分析。结果患者血清的annexin A1、LDL-C、NK-κB、IL-6水平在男女之间差别均未见统计学意义,P>0.05。LDL-C、NK-κB、IL-6水平异常增高组患者的annexin A1水平低于非增高患者水平,且在不同性别患者中均如此,差别均有统计学意义,P<0.05。annexin A1水平与血清LDL-C、NK-KB、IL-6水平均表现负相关关联,且均P<0.05;在男性患者和女性患者中也分别观察到类似趋势。结论冠心病患者中的血清annexin A1的血清表达水平同LDL-C、NK-κB、IL-6水平负相关,见于LDL-C、NK-κB、IL-6水平增高与冠心病病情的恶化相关联,因此推知annexin A1在体内减缓冠心病病情恶化。
Objective To analyze the correlation of sera low density lipoprotein cholesterol（ LDL-C）, nuclear transcription factor-kappa B（ NK- κB ） , interleukin-6 （ IL-6 ） and annexin A1 in patients with coronary heart disease（CHD）. Methods 80 patients with CHD diagnosed in our hospital were enrolled in this study. The correlation among sera levels of LDL-C, NK-κB, IL-6 and annexin A1 was studied. SPSS17.0 statistical package was used for analysis and processing of data. Results There was no significant difference in serum annexin A1 expression, LDL-C, NK-κB and IL-6 levels between male and female patients, P 〉 0.05. The level of annexin A1 in patients with abnormal high level of LDL-C, NK-κB and IL-6 was significantly lower than that of non - heighten patients in both genders, P 〈 0.05. The levels of annexin A1 were negatively correlated with serum LDL-C,NK-κB and IL-6 levels in both genders,P 〈 0.05. Conclusion The serum level of annexin A1 of patients with coronary heart disease is negatively correlated with the levels of LDL- C, NK-κB and IL-6. The Higher levels of LDL-C, NK-κB and IL-6 are associated with the worsening of coronary heart disease, which suggests that annexin A1 in vivo could slow down the progression/worsening of coronary heart disease.
作者
侯文华
肖传宇
谢强
HOU Wen-hua;XIAO Chuan-yu;XIE Qiang(Department of Clinical Laboratory,The First People＇s Hospital of Zaoyang,Zaoyang 441200,China)
出处
《标记免疫分析与临床》
CAS
2018年第8期1148-1150,1171,共4页
Labeled Immunoassays and Clinical Medicine
