摘要
目的:探讨IL-1β、IL-1受体拮抗剂(IL-1Ra)、IL-10、IL-6水平及IL-1Ra/IL-1β、IL-10/IL-6比值在冠状动脉粥样硬化性心脏病(冠心病)患者血清中的变化以及临床意义。方法:选择稳定型心绞痛(SAP)患者26例,不稳定型心绞痛(UAP)患者27例,AMI患者27例,健康体检者30名,分为SAP组、UAP组、AMI组及正常对照组,采用ELISA法检测四组患者血清IL-1β、IL-1Ra、IL-10、IL-6水平,计算IL-1Ra/IL-1β、IL-10/IL-6比值,并进行比较。结果:UAP组、AMI组患者的血清IL-1Ra水平均明显低于正常对照组(P<0.05),IL-1β高于对照组(P<0.05);三组冠心病患者的IL-1Ra/IL-1β比值均低于正常对照组(P<0.05)。三组冠心病患者的血清IL-10、IL-6水平均高于正常对照组(P均<0.05),而IL-10/IL-6比值低于正常对照组(P均<0.05)。结论:IL-1β、IL-1Ra、IL-10、IL-6可能参与了冠心病的炎症反应过程,IL-1Ra/IL-1β及IL-10/IL-6比值反映了冠心病患者的免疫调节状况,其比值高低及动态变化对冠心病患者的病情监测有重要参考价值。
Objective： To investigate the clinical significance of interleukin-1β（IL-1β）,interleukin-1 receptor antagonist（IL-1Ra）,interleukin 10（IL-10）,interleukin-6（IL-6） and the ratio of IL-1Ra/IL-1β,IL-10/IL-6 in coronary heart disease（CHD）.Methods： Patients with stable angina pectoris（SAP group,n=26）,unstable angina pectoris（UAP group,n=26）,and acute myocardial infarction（AMI group,n=27） were involved.Thirty healthy people were selected as control group.Serum level of IL-1β,IL-1Ra,IL-10,IL-6 were detected by Enzyme-linked immunosorbent assay（ELISA） and the ratio of IL-1Ra/IL-1β and IL-10/IL-6 were calculated.Results： The serum level of IL-1Ra in UAP group and AMI group were significantly lower,and IL-1β levels were significantly higher than that in control group（P0.05）.IL-1Ra/IL-1β ratio in CHD patients was lower than in control group（P0.05）.The serum levels of IL-10,IL-6 in CHD patients were higher while IL-10/IL-6 ratio was lower than in control group（P0.05）.Conclusions： IL-1β,IL-1Ra,IL-10,IL-6 may be involved in the pathogenesis of CHD.The ratio of IL-1Ra/IL-1β and IL-10/IL-6 in CHD patients can reflect the immune regulation.The ratios degree and dynamic variation are of reference value in monitoring the status of CHD patients.
出处
《新医学》
2012年第6期379-382,共4页
Journal of New Medicine
