摘要
目的评估难治性精神分裂症(TRS)患者认知功能的状况及可能的危险因素。方法选取36名难治性精神分裂症患者(难治组)和57名非难治性患者(非难治组)及50名健康人(对照组)入组,采用重复性成套神经心理状态测验(RBANS)评估所有参与者的神经认知功能。采用阳性和阴性症状量表(PANSS)评估患者的精神症状。结果患者组认知功能差于正常组,TRS认知功能差于非TRS患者,差异具有统计学意义(P<0.05)。多元回归分析显示高含量抗胆碱能的抗精神病药物是患者即刻记忆(β=12.242,t=11.271,P=0.000)和延时记忆(β=7.391,t=3.354,P=0.001)损害的独立危险因素,阴性症状是注意功能(β=11.147,t=9.436,P=0.002)损害的独立危险因素。结论 TRS比非TRS患者拥有更严重的认知功能缺陷。抗精神病药物(高含量抗胆碱能活性)和阴性症状是影响TRS患者认知功能的危险因素。
Objective The aim of this study was to evaluate cognitive function impairment and its risk factors of patients with treatment-resistant schizophrenia（TRS）. Method 36 TRS patients and 57 non-TRS and 50 healthy controls subjects were enrolled in the study. Psychiatric symptoms（except for healthy controls）and cognitive functioning were evaluated. Results The schizophrenia patients had a moe severe cognitive impairment than the normal group. And TRS patients were worse than non-TRS patients（P〈0.05）. Multiple regression analysis showed that high anticholinergic activity of antipsychotics had debilitating effect on immediate memory（β=12.242,t=11.271,P=0.000）and delayed memory（β=7.391,t=3.354,P=0.001）,negative symptoms were independent risk factors for attention（β=11.147,t=9.436,P=0.002）. Conclusion Cognitive deficits are more severe in TRS patients than in non-TRS subjects,and antipsychotics that exert high anticholinergic activity as well as negative symptoms were the risk factors.
作者
李广新
余逗逗
马利
乔云飞
肖文焕
LI Guangxin;YU Doudou;MA Li(Wutaishan Hospital of Medical college of Yangzhou University,Yangzhou 225003,China)
出处
《国际精神病学杂志》
2018年第4期629-631,641,共4页
Journal Of International Psychiatry
关键词
精神分裂症
难治性
认知功能
危险因素
Schizophrenia
Treatment resistance
Cognitive function
Risk factor
