摘要
目的探讨普拉洛芬滴眼液联合人工泪液对干眼症患者症状改善及泪膜破裂时间的影响。方法选取2014年5月~2017年9月郏县妇幼保健院治疗的干眼症患者94例(188眼),依照随机抽签法分为观察组和对照组,每组各47例(94眼)。对照组予以人工泪液治疗,观察组于对照组基础上采取普拉洛芬滴眼液治疗。两组14d为1个疗程,持续用药2个疗程后统计对比两组治疗效果及治疗前后泪膜破裂时间、角膜荧光素染色评分、干眼症调查问卷(SEEQ)评分变化。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05);治疗后与对照组相比,观察组泪膜破裂时间延长、SEEQ评分及角膜荧光素染色评分降低,差异有统计学意义(P<0.05)。结论普拉洛芬滴眼液联合人工泪液治疗干眼症疗效显著,可明显改善患者症状及角膜缺损情况,并延长泪膜破裂时间。
Objective To investigate the effect of pranoprofen eye drops combined with artificial tears on the symptom improvements and tear film break-up time in patients with xerophthalmia. Methods A total of 94 cases（188 eyes） of xerophthalmia treated in Jiaxian maternal and child health care hospital from May 2014 to September 2017 were randomly divided into the observation group and the control group with 47 cases（94 eyes） in each group. The control group was treated with artificial tears, while the observation group was treated with pranoprofen eye drops based on the control group. There were 14 d in 1 course, and both groups were treated continuously for 2 courses. Then the therapeutic effect, the tear film break-up time before and after treatment, the corneal fluorescein staining score and the dry eye questionnaire（SEEQ） score were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group（P〈0.05）. Compared with the control group, the tear film break-up time was prolonged, and the SEEQ score and corneal fluorescein staining score decreased in the observation group（P〈0.05）. Conclusion The effect of pranoprofen eye drops combined with artificial tears in patients with xerophthalmia is significant. It can obviously improve the patient＇s symptoms and corneal defect, and prolong the tear film break-up time.
作者
宋艳琳
SONG Yan-lin(Department of Ophthalmology,Jiaxian maternal and child health care hospital,Pingdingshan,Henan,467100,China)
出处
《临床研究》
2018年第10期22-23,共2页
Clinical Research
关键词
干眼症
普拉洛芬滴眼液
人工泪液
xerophthalmia
pranoprofen eye drops
artificial tear
