摘要
随着世界人口的老龄化，新诊断的痴呆正以每年7700000例的速度增长，这一疾病严重影响老年人的功能和生活质量。因此早期发现痴呆高危人群并采取有效的措施是该疾病的预防重点。越来越多的研究表明，在诊断痴呆综合征前，许多老年人普遍存在步态缓慢，并认为步态缓慢是预测痴呆的有力因子。因此将步态纳人痴呆风险评估是一种既能提高痴呆预测风险能力又简便的新方法。运动认知功能减退综合征（motoric cognitive risk syndrome，MCR）是一种以在非痴呆老年人群中同时存在步态缓慢和主观认知功能减退为特点，并用于预测痴呆风险的新型综合征。另外，相关研究表明MCR也是其他老年性疾病如摔倒、残疾和死亡等的有效预测工具。然而在国内对该综合征认识仍存在欠缺。因此我们对MCR包括发病机制、诊断、流行病学及其与老年性疾病之间的关系做一综述，旨在为临床提供一定的指导。
As the population ages worldwide, dementia patients increase at a high rate of 7.7 million each year, which has a huge impact on quality of life of the elder. It is not surprising, therefore, that early detection of individuals at high risk for dementia and the development of effective interventions are major public health priorities. There is increasing evidence that gait slowing occurs early in the course of dementia, precedes declines in cognitive tests, and is a strong predictor of dementia. Hence, incorporating gait performance into risk assessments is a novel and simple approach that can help improve dementia prediction. The motoric cognitive risk syndrome （MCR） is a predementia syndrome characterized by the presence of cognitive complaints and slow gait in older individuals without dementia or mobility disability. In addition, studies have shown MCR as a predictor of other negative outcomes in older adults, including disability, falls and death. However, the concept of MCR is still in its early stage and approach to the syndrome is not yet well established in China. This review aims to demonstrate the various aspects of MCR syndrome including its pathophysiology, diagnosis, epidemiology, and relationship with other geriatric conditions.
作者
程峙娟
涂江龙
Cheng Zhijuan;Tu Jianglong(Department of Neurology,the Second Affiliated Hospital of Nanchang University,Nanchang 330006,Chin)
出处
《中华神经科杂志》
CAS
CSCD
北大核心
2018年第8期638-642,共5页
Chinese Journal of Neurology
关键词
痴呆
步态
痴呆风险
认知
老龄化
Dementia
Gait
Dementia risk
Cognition
Aging
