摘要
目的 探讨事件相关电位（ERP）在颅脑外伤后智能损害评估中的应用.方法 选取60例颅脑外伤后智能损害患者作为病例组,同时选取60例健康的受试者作为正常对照组,应用脑电生理仪记录并比较两组的P300和P50的差异.结果 患者组P300[（440.430±77.367） ms]较对照组[（342.928 ± 36.175） ms]潜伏期显著延长（P＜0.01）、波幅降低[患者组（12.692±8.152） μV,对照组（18.138 ±6.590） μV,P＜0.01].患者组S2-P50波幅明显高于对照组[患者组（3.75±1.59） μV,对照组（2.42 ± 1.43） μV,P＜0.01],S2-P50波幅/SI-P50波幅的比值明显大于对照组[患者组：（0.78±0.54）,对照组：（0.46±0.18）,P＜0.01].患者P300潜伏期和波幅与WAIS-RC总智商分呈显著相关（r=-0.31,P＜0.01;r=0.17,P＜0.01）;S2-P50的波幅和S2-P50波幅与SI-P50波幅的比值均与WAIS-RC总智商分显著呈负相关（r=-0.33,P＜0.01;r=-0.45,P＜0.01）.结论 ERP的P300和P50成分可为颅脑外伤后智能损害的司法鉴定提供参考.
Objective To investigate the changes of event-related potentials （ERPs） in patients with intelligence impairments after craniocerebral trauma.Methods 60 patients with intelligence impairments after craniocerebral trauma were enrolled as case group,and 60 healthy subjects were enrolled as control group.EEG instrument was used to record P300 and P50 of the two groups and the differences in P300 and P50 components were compared.Results There are significant differences between case group and control group in latency of P300 （（440.430 ± 77.367） ms vs （342.928 ± 36.175） ms,P〈 0.01）,and case group showed decreased amplitude （（12.692±8.152） μV vs （18.138±6.590） μV,P〈0.01）.The S2-P50 amplitude of case group was significantly higher than that of control group （（3.75± 1.59） μV vs （2.42±1.43） μV,P〈0.01）.In addition,the S2-P50 amplitude/S1-P50 amplitude ratio of case group was higher than that of the control group,and the difference was statistically significant （0.78±0.54 vs 0.46±0.18,P〈0.01）.The latency and amplitude of P300 were significantly correlated with the total score of WAIS-RC （r=-0.31,P〈0.01;r=0.17,P〈0.01）;The amplitude of S2-P50 and the ratio of S2-P50 amplitude to S1-P50 amplitude were significantly negatively correlated with the total score of WAIS-RC （r=-0.33,P〈0.01;r=-0.45,P〈0.01）.Conclusion P300 and P50 components of ERP can provide references for judicial expertise to evaluate intelligence impairments after craniocerebral trauma.
作者
陈素玲
黄子夜
贾碎林
陈小帆
陈亚林
陈兴时
Chen Suling, Huang Ziye, Jia Suilin, Chen Xiaofan, Chen Yalin, Chen Xingshi(Department of Psychiatry, Wenzhou Seventh People＇ s Hospital, Wenzhou 325005, China ; Department of Psychiatry, Shanghai Mental Health Center, Shanghai 200030, China)
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2018年第8期749-752,共4页
Chinese Journal of Behavioral Medicine and Brain Science
基金
温州市第二期科技计划项目（Y20140420）
温州市医药卫生科学研究项目计划A类（Y2014A07）
关键词
事件相关电位
颅脑外伤
智能损害
司法鉴定
Event-related potential
Craniocerebral trauma
Intelligence impairments
Judi-cial expertise
