摘要
目的探讨保乳手术与改良根治术对较年轻的早期乳腺癌患者预后及生存质量的影响。方法选取自2010年1月至2012月12月首次于上海市同仁医院行手术治疗的较年轻的早期乳腺癌患者114例,根据手术方式分为改良根治组(n=64)与保乳手术组(n=50)。对患者进行随访,通过复发、转移情况和存活率评价患者预后,通过乳腺癌患者生命质量测定量表(FACT-B)中文版问卷评估患者生存质量。结果随访期间,改良根治组复发率为4.7%(3/64),保乳手术组复发率为4.0%(2/50),两组间比较,差异无统计学意义(P>0.05);两组患者均未发生远处转移,5年存活率均为100.0%,两组间比较,差异无统计学意义(P>0.05)。术后3个月,保乳手术组患者FACT-B中文版的生理、社会/家庭情况、情感、功能、乳腺癌附加关注领域评分及总分均高于改良根治组,差异有统计学意义(P<0.05)。术后1年及5年,保乳手术组患者FACT-B中文版的情感、功能、乳腺癌附加关注领域评分及总分均高于改良根治组,差异有统计学意义(P<0.05)。结论于较年轻的早期乳腺癌患者,保乳手术与改良根治术的复发率、5年存活率相似,但保乳手术能显著提高患者的生存质量。
Objective To investigate whether breast conserving surgery or modified radical mastectomy were helpful in improving prognosis and quality of life in young patients with early breast cancer. Methods A total of 114 cases of breast cancer were treated in Shanghai Tong Ren hospital from January 2010 to December 2012,64 cases in modified radical operation group and 50 cases in breast conserving surgery group. The patients＇ prognosis was evaluated by metastasis,and survival and the quality of life was evaluated by the questionnaire of Chinese version of FACT-B. Results During the follow-up period,the recurrence rate of the modified radical group was 4. 7%（ 3/64）,and the breast conserving surgery group was 4. 0%（ 2/50）. There was no significant difference between the two groups（ P〈0. 05）. There was no distant metastasis in both two groups,and the 5 year survival rate was 100. 0% in both two groups. The total scores and scores of physiology,social/family,emotion,function and additional attention of breast cancer of FACT-B（ Chinese version） in the breast conserving surgery group were higher than those in the modified radical mastectomy group（ P〈0. 05）. Conclusion For younger patients with early breast cancer,breast conserving surgery and modified radical mastectomy have similar recurrence rate and 5 year survival rate,but it could significantly improve their quality of life.
作者
孙超
金薇
SUN Chao;JIN Wei(Department of General Surgery,Shanghai Tong Ren Hospital,Shanghai 200336,China)
出处
《临床军医杂志》
CAS
2018年第8期892-893,896,共3页
Clinical Journal of Medical Officers
基金
上海市医学重点专科(ZK2015A25)
关键词
乳腺癌
保乳手术
改良根治术
生存质量
Breast cancer
Breast conserving surgery
Modified radical mastectonly
Quality of life
