摘要
目的探讨胰岛素抗体在Ⅰ型糖尿病(T1DM)和2型糖尿病(T2DM)患者的临床分型诊断中的价值。方法选取该院于2015年6月—2017年6月收治的100例糖尿病患者作为研究对象,其中Ⅰ型40例,2型60例。比较不同分型糖尿病患者的胰岛素抗体水平以及相关生化指标的状态。结果 INS-Ab阳性组、阴性组患者餐后2 h的INS、CP水平均显著增加,其中阳性组餐后2 h的INS显著高于INS-Ab阴性组患者;Ⅰ型糖尿病患者的胰岛自身抗体(IAA-Ab、ICA-Ab以及GAD-Ab)阳性率均明显高于2型糖尿病患者,且Ⅰ型糖尿病患者的3种抗体联合检测时的阳性率显著高于单项检测,差异有统计学意义(P<0.05)。结论糖尿病患者血清中的胰岛素抗体阳性率的检测对T1DM与T2DM的临床分型诊断有一定的指导价值,有利于对糖尿病的正确分型、早期预测,提供有效依据。
Objective To study the value of insulin antibody in the clinical typing diagnosis of T1DM and T2DM. Methods100 cases of diabetes patients admitted and treated in our hospital from June 2015 to June 2017 were selected and divided into two groups, including 40 cases with type Ⅰ diabetes and 60 cases with type 2 diabetes, and the insulin antibody level and related biochemical indicators were compared between the two groups. Results The postprandial 2 hINS and CP levels in the INS-Ab positive group and negative group obviously increased, and the postprandial 2 hINS in the positive group was obviously higher than that of INS-Ab negative group, and the insulin antibody of patients with type Ⅰ diabetes IAA-Ab, ICA-Ab and GAD-Ab was obviously higher than that of patients with type 2 diabetes, and the combined test positive rate of patients with type Ⅰ diabetes was obviously higher than that of single test, and the difference was statistically significant（P〈0.05）. Conclusion The test of insulin antibody positive rate in serum of diabetes patients has a certain guidance value in the clinical classification diagnosis of T1DM and T2DM, which is conductive to the accurate typing and early predication of diabetes, thus providing effective reference.
作者
刘丽雅
方跃亭
洪清楚
LIU Li-ya;FANG Yue-ting;HONG Qing-chu(Department of Clinical Laboratory,Xiamen Fifth Hospital,Xiamen,Fujian Province,361101 China)
出处
《糖尿病新世界》
2018年第3期27-29,共3页
Diabetes New World Magazine
