摘要
目的探讨外源性胰岛素抗体综合征（EIAS）的临床特点。方法回顾性分析3例住院EIAS患者的一般资料和实验室指标。结果 EIAS患者年龄63~81岁,糖尿病病程10~22年,低血糖发作1例,发作时间无规律;均无自身免疫病病史和含巯基药物接触史;血清ICA、GADAb均阴性,IAA均强阳性（〉100）;血清胰岛素水平均升高,但与C-P水平不匹配;调整为口服药或减少胰岛素注射次数后,血糖控制均改善。结论高胰岛素血症伴或不伴低血糖的T2DM患者,如发现血清胰岛素浓度与C-P水平不匹配,需检测胰岛素抗体（IAb）,并考虑EIAS的可能性,必要时调整为口服药治疗可改善血糖控制。
Objective To explore the clinical characteristics of exogenous insulin antibody syndrome（EIAS）.Methods The general data and laboratory index of 3 EIAS inpatients were retrospectively analyzed.Results EIAS patients was aged 63~81years and courses were 10~22years.One patient had no regular pattern of the onset time of hypoglycemia.All subjects had no history of autoimmune disease and did not use the drugs containing the hydrosulfide group.The islet cellular antibody and glutamic acid decarboxylase antibody were all negative,and insulin autoantibody were all positive;the serum insulinlevels were high in these patients,but disproportional with the C-P level;After adjusting for oral hypoglycemic drugs and discontinuing of insulin or reducing the doses of insulin,blood glucose control was improved.Conclusion It’s necessary to measure insulin antibody（IAb）and consider the possibilities of EIAS.If patients have hyperinsulinemia or have disproportional hyperinsulinemia with the serum C-P levels,adjusting for oral hypoglycemic drugs and discontinuing of insulin or reducing the doses of insulin can improve glucose control.
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2015年第6期512-515,共4页
Chinese Journal of Diabetes
