摘要
目的探讨氨酚羟考酮缓释片治疗中晚期恶性肿瘤疼痛的临床效果及其安全性。方法选取收治的中晚期恶性肿瘤患者128例,随机分为研究组和对照组,各64例,研究组采用氨酚羟考酮缓释片进行镇痛,对照组患者采用口服吗啡制剂镇痛。将两组患者在治疗中的疼痛缓解度、生活质量和不良反应发生情况进行对比。结果研究组治疗后疼痛缓解率为95.59%,明显低于对照组(P<0.05);研究组患者食欲、睡眠、日常生活、精神状态及与人交往五个方面的生活质量显著高于对照组(P<0.05);研究组各项不良反应发生例数均少于对照组(P<0.05)。结论氨酚羟考酮缓释片治疗中晚期恶性肿瘤疼痛中可以显著缓解患者的疼痛感,提高生活质量,减少不良反应的发生,在临床上的应用价值很高。
Objective To investigate the clinical efficacy and safety of oxycodone acetaminophen sustained-release tablets in the treatment of pain in patients with advanced malignant tumors. Methods 128 patients with middle and late stage malignant tumor were selected and divided into the study group and the control group randomly,each with 64 cases.The study group used oxycodone acetaminophen slow-release tablets for analgesia,and the control group was treated with oral morphine to relieve pain.The pain relief,quality of life and adverse reactions of the 2 groups were compared. Results The pain relief rate of the study group was 95.59%,which was significantly lower than that of the control group （ P 〈0.05）,and the quality of life in appetite,sleep,daily life,mental state and interpersonal communication in the study group was significantly higher than that of the control group （ P 〈0.05）,and the number of adverse events in the study group was less than that of the control group （ P 〈0.05）. Conclusion oxycodone acetaminophen sustained-release tablets can significantly alleviate pain in patients with advanced malignant tumor,improve the quality of life,reduce the incidence of adverse reactions,and have a high clinical value.
作者
刘素荣
魏媛媛
徐艳丽
李新红
刘娟
秦燕
LIU Surong;WEI Yuanyuan;XU Yanli;.The 521 Hospital of Ordnance Industry;Xi＇an;710065
出处
《实用癌症杂志》
2018年第7期1121-1123,1130,共4页
The Practical Journal of Cancer
关键词
氨酚羟考酮缓释片
中晚期恶性肿瘤
疼痛
临床效果
Oxycodone acetaminophen sustained- release tablets
Advanced malignancy
Pain
Clinical effects
