摘要
目的探讨特布他林治疗小儿支原体肺炎的临床效果。方法将我院90例支原体肺炎患儿按随机数表法分为观察组与对照组各45例。两组均给予阿奇霉素序贯治疗,观察组同期另给予特布他林。对比两组临床疗效、临床症状消失时间、气道炎症相关因子及肺功能指标变化,并记录不良反应发生率。结果观察组总有效率95.56%高于对照组82.22%(P<0.05)。观察组发热消失时间、咳嗽消失时间、肺部啰音消失时间、喘息消失时间均显著短于对照组(P<0.05)。观察组治疗后EOS、IL-2低于对照组,IL-4、FEV1、PEF、FEV1/FVC高于对照组(P<0.05)。不良反应发生率比较无统计学意义(P>0.05)。结论特布他林联合阿奇霉素序贯治疗小儿支原体肺炎可减轻气道炎症反应,改善肺功能,安全性高。
Objective To explore the clinical effect of terbutaline in treatment of children with mycoplasma pneumonia. Methods 90 children with mycoplasma pneumonia in our hospital were randomly divided into the observation group and the control group. All children were treated with azithromycin sequential therapy,and the observation group was given terbutaline. The clinical effect,the disappearance time of clinical symptoms,the related factors of airway inflammation and the changes of lung function index were compared between the two groups,and the incidence of adverse reactions was recorded. Results The total effective rate of the observation group was 95. 56%,higher than 82. 22% of the control group（ P〈0. 05）. The fever disappearance time,cough disappearance time,lung rale disappearance time and wheezing disappearance time of the observation group were significantly shorter than those of the control group（ P〈0. 05）. The levels of EOS and IL-2 were lower in the observation group than in the control group,and the levels of IL-4,FEV1,PEF and FEV1/FVC were higher in the observation group than in the control group（ P〈0. 05）. The incidence of adverse reactions in the two groups was not statistically significant（ P〉0. 05）. Conclusion Terbutaline combined with azithromycin in the sequential treatment of children with mycoplasma pneumonia can reduce airway inflammation and improve lung function,which has high safety and is worthy of being popularized in clinical use.
作者
侯小瑞
靳瑞霞
谢意茹
HOU Xiao-rui;JIN Rui-xia;XIE Yi-ru(the Eighth People＇s Hospital of Anyang,Anyang,Henan 456150,China)
出处
《临床肺科杂志》
2018年第8期1439-1442,共4页
Journal of Clinical Pulmonary Medicine
关键词
特布他林
阿奇霉素
小儿支原体肺炎
肺功能
气道炎症
terbutaline
azithromycin
mycoplasnla pneumonia in children
pulmonary function
airway inflamnlation
