摘要
目的:探讨尼莫地平联合盐酸多奈哌齐对脑梗死认知障碍患者的治疗效果及对生活质量的影响。方法:选择2016年1月至2016年12月我院接诊的脑梗死后认知障碍患者82例,随机分为观察组和对照组,各41例。对照组患者采用盐酸多奈哌齐进行治疗,观察组患者在此基础上联合尼莫地平进行治疗。比较两组患者临床疗效及治疗前后的美国国立卫生研究院卒中量表(NIHSS)评分、蒙特利尔认知评估量表(Mo CA)评分、运动功能评定量表(Fugl-meyer)评分及不良反应。结果:经治疗,观察组临床有效率显著高于对照组[92.68%(38/41)vs 73.17%(30/41)](P<0.05);观察组NIHSS评分显著低于对照组[(3.87±1.33)vs(5.56±1.85)分](P<0.05);观察组患者Mo CA评分明显高于对照组[(26.53±5.71)vs(22.02±5.47)分](P<0.05);观察组患者Fugl-meyer评分显著高于对照组[(84.57±6.13)vs(73.13±6.02)分](P<0.05);观察组患者不良反应总发生率低于对照组[14.63%(6/41)vs 41.46%(17/41)](P<0.05)。结论:尼莫地平联合盐酸多奈哌齐治疗脑梗死认知障碍疗效确切,可明显改善患者神经缺损、认知功能及机体运动功能,改善患者生活质量,且安全性较高,效果优于单独应用盐酸多奈哌齐,值得应用推广。
Objective： To study the effect of Nimodipine combined with donepezil hydrochloride on cognitive impairment and quality of life in patients with cerebral infarction. Methods： 82 patients of cognitive impairment after cerebral infarction who received therapy from Jan. 2016 to Dec. 2016 in our hospital were selected. According to random number table,The patients were divided into the observation group and the control group,41 cases of each group. Patients in the control group were treated with donepezil hydrochloride,and patients in the observation group were treated with nimodipine on this basis. The clinical efficacy and NIHSS score,Montreal Cognitive Assessment Scale（Mo CA） score,motor function scale（Fugl-meyer score） and adverse reactions were compared between the two groups before and after treatment. Results： After treatment,the clinical efficiency of the observation group was significantly higher than that of the control group 92.68%（38/41） vs 73.17%（30/41）（P0.05）; The NIHSS score in observation group was significantly lower than that in control group（3.87±1.33） vs（5.56±1.85） score（P 0.05）; The Mo CA score in observation group was significantly higher than that in control group（26. 53 ± 5. 71） vs（22. 02 ± 5. 47） score（P 0. 05）; The Fugl-meyer score in observation group was significantly higher than that in control group（84. 57 ± 6. 13） vs（73.13±6.02） score（P0.05）; The total incidence of adverse reactions in observation group was lower than that in control group 14. 63%（6/41） vs 41. 46%（17/41）（P 0. 05）. Conclusion： Nimodipine combined with donepezil hydrochloride is effective in the treatment of cognitive impairment of cerebral infarction. It can obviously improve the nerve defect,cognitive function and motor function of the patients,and improve the quality of life of the patients with high safety. The effect is better than the use of donepezil alone. It is worthy of application.
作者
王建峰
张晨红
王婉
吕日琅
WANG Jianfeng;ZHANG Chenhong;WANG Wan(No.215 Hospital of Shaanxi Nuclear Industry,Shaanxi Xianyang 712000,China)
出处
《河北医学》
CAS
2018年第8期1273-1277,共5页
Hebei Medicine
基金
陕西省自然科学基金资助项目
(编号:2011232)
关键词
尼莫地平
盐酸多奈哌齐
脑梗死
认知障碍
Nimodipine
Donepezil hydroehloride
Cerebral infarction
Cognitive impaimlent
