摘要
目的探讨不同剂量丁二磺酸腺苷蛋氨酸注射剂对重度淤胆型肝炎黄疸的临床效果。方法选择2014年1月至2017年4月恩施州中心医院感染科收治的80例重度淤胆型肝炎患者作为研究对象,按随机数字表法分为对照组与试验组,每组40例。对照组采用1 000 mg丁二磺酸腺苷蛋氨酸注射剂治疗,试验组采用2 000 mg丁二磺酸腺苷蛋氨酸注射剂治疗,比较2组治疗效果,观察治疗前后患者临床症状及体征的变化情况,测定治疗前后患者谷丙转氨酶(ALT)、碱性磷酸酶(ALP)、谷氨酰转肽酶(GGT)、总胆红素(TBi L)、总胆汁酸(TBA)水平的变化,统计不良反应发生率。结果试验组治疗总有效率高于对照组(P<0.05)。治疗前,2组肝肿大、皮肤瘙痒、纳差、乏力、尿黄等症状所占比例比较差异无统计学意义(P>0.05)。治疗后,2组上述症状所占比例均降低,试验组皮肤瘙痒所占比例低于对照组,差异有统计学意义(P<0.05)。治疗前,2组ALT、ALP、GGT、TBi L、TBA比较差异无统计学意义(P>0.05)。治疗后,2组上述指标均降低,差异有统计学意义(P<0.05),试验组降低幅度高于对照组,差异有统计学意义(P<0.05);2组治疗期间均未出现不良反应。结论丁二磺酸腺苷蛋氨酸注射剂可减轻重度淤胆型肝炎患者黄疸程度,改善患者肝功能,尤其以大剂量丁二磺酸腺苷蛋氨酸注射剂疗效明显,且安全性高。
Objective To investigate clinical effects of different doses of ademetioninel, 4-butanedisulfonate injection on jaundice in severe cholestatic hepatitis. Methods Eighty patients with severe cholestatic hepatitis hospitalized from January, 2014 to April, 2017 were enrolled as the research subjects, and were randomly divided into the control group （or group A） and the experimental group （or group B）, each consisting of 40 patients. The patients in the control group received 1000 mg ademetionine 1,4-butanedisul fonate injection, while those patients in the experimental group were treated with 2000 mg of ademetioninel, 4-butanedisulfonate injection. Then, therapeutic effects were compared between the 2 groups, and changes in clinical symptoms and signs before and after treat- ment were closely observed. The levels of alanine aminotransferase （ALT）, alkaline phosphatase （ALP）, glutamyl transpeptidase （GGT）, total bilirubin （TBiL） and total bile acid （TBA） were determined before and after treatment, and the incidence of adverse reactions was also statistically analyzed. Results Total effective rate of group B was higher than that of group A （ P 〈 0.05 ）. Before treatment, there was no statistical significance in such clinical symptoms as hepatomegaly, skin pruritus, anorexia, fatigue and yellow urine, when comparisons were made between the 2 groups （P 〉 0.05 ）. After treatment, the percentages of the above symptoms in the two groups all decreased, but the percentages of skin pruritus in group B was lower than flint in group A, with statistical significance （ P 〈 0.05 ）. Before treatment, there were no significant differences in the levels of ALT, ALP, GGT, TBiL and TBA, when comparisons were made between the 2 groups （P 〉 0.05）. After treatment, the above indexes in the 2 groups all decreased, with statistical signifi-cance （P 〈0.05 ）. However, the amplitude of decrease in group B was greater than that in group A, also with statistical significance （P 〈 0.05
作者
段俊
葛舰
任方元
Duan Jun;Ge Jian;Ren Fangyuan(Department of Infectious Diseases,Enshi Central Hospital,Enshi 445000,Chin)
出处
《海军医学杂志》
2018年第4期351-354,共4页
Journal of Navy Medicine
关键词
肝炎
胆汁淤积
丁二磺酸腺苷蛋氨酸
剂量
肝功能
Hepatitis
Cholestasis
Ademetioninel
4-butanedisulfonate
Dose
Liver function
