摘要
目的了解长沙市健康人群流行性腮腺炎(流腮)抗体水平,为防控策略提供依据。方法选取长沙市健康人群进行问卷调查并采集血清,采用ELASA法检测Ig G抗体。结果 1 512名健康人群流腮抗体阳性率为77.65%,抗体几何平均浓度为(GMC)为315.18IU/mL。抗体阳性率及GMC无性别间差异无统计学意义(χ~2=0.088,P=0.767;H=0.660,P=0.416);5区(县)抗体阳性率不完全一致(χ~2=13.453,P=0.009),GMC差异无统计学意义(H=2.284,P=0.684);各年龄组抗体阳性率及GMC不完全一致(χ~2=342.592,P=0.000;H=244.627,P=0.000),8~17月龄抗体阳性率最低(24.22%),15~19岁组次之(28.86%),≥40岁组抗体阳性率最高(100.00%),8~17月龄组GMC最低(0 IU/mL),30~39岁组GMC最高(459.07 IU/mL);含流腮成分疫苗各剂次间抗体阳性率和GMC不完全一致(χ~2=241.392,P=0.000;H=195.415,P=0.000)。结论长沙市流腮抗体阳性率及抗体水平均较高,隐性感染较多,男女均易感,全市流腮防控应以流动儿童为重点,目前1剂次流腮疫苗接种策略可靠有效。
Objective To analyze the mumps antibody level in the healthy population in Changsha, and provide a scientific basis for preventing mumps epidemic. Methods Healthy population was investigated, questionnaire and serum samples were collected, IgG antibody of mumps was detected by ELASA. Results The positive rate and the GMC of mumps antibody of the healthy population （ 1 512） were 77. 65% and 315. 18IU/mL respectively. There was no significant difference between male and female in antibody positive rate and GMC（x2 =0. 088, P =0. 767; H = 0. 660, P =0. 416）. The positive rate of mumps antibody in 5 districts was not identical （X2 = 13. 453, P =0. 009）, no significant difference in GMC in 5 districts（ H = 2. 284, P = 0. 684）. Positive rate of antibody of each age group was not the same（x2 = 342. 592, P = 0. 000）, 8 - 17 months group was the lowest （24. 22% ）, 15 - 19 age group took the second place （28.86%） and the highest rate was in the 40 or above group （ 100% ）. GMC of 8 - 17 months group was the lowest （0 IU/mL）, 30 -39 group was the highest （459. 07 IU/mL）. The antibody positive rate and GMC of the mumps vaccine content were not exactly the same （ H =241. 392, P = 0. 000）. Conclusion The positive rate and the level of GMC of mumps antibody were both quite high in Changsha. There were many latent infections of mumps. Both male and female were susceptible. The control of mumps epidemic should focus on mobile children in the city, the strategy of one-dose mumps vaccine was effective and reliable. The present vaccination strategy is reliable and effective.
作者
刘姝
林希建
刘浩
LIU Shu;LIN Xijian;LIU Hao(Changsha Center for Disease Control and Prevention,Changsha 410001,China)
出处
《公共卫生与预防医学》
2018年第4期40-42,共3页
Journal of Public Health and Preventive Medicine
