摘要
酒精性肝病(ALD)在中国内蒙古地区较常见,主要与当地不良饮酒习惯有关,其对人们的生活造成很大影响,甚至危及生命。近年来,ALD基因的研究在内蒙古逐步进行,多种基因对ALD的影响深远。其中,高迁移率族蛋白B1(HMGB1)作为一种新型的晚期致炎因子和内源性损伤相关分子模式配体,在肝脏组织损伤的发生、发展过程中占重要地位,不仅能诱导ALD,促进其进一步发展为肝硬化,还参与肝癌的发生、发展。同时,HMGB1的基因多态性与ALD遗传易感性相关。但其具体机制尚不明确,未来需进一步研究。
Alcoholic liver disease（ ALD） is common in Inner Mongolia area,which is mainly related to bad drinking habits. It has great impact on people＇s lives and even endangers life. In recent years,studies on the genes of ALD have been progressively carried out in Inner Mongolia,and it＇s discovered that many genes have a far-reaching impact on ALD. Among them,the high-mobility group box-1（ HMGB1） as a new type of late inflammatory factors and endogenous damage associated molecular patterns of ligand,plays an important role in the occurrence and development of liver tissue damage. It not only can induce ALD and promote the further development of liver cirrhosis,but also is involved in the occurrence and development of hepatocellular carcinoma. At the same time,the gene polymorphism of HMGB1 is associated with ALD genetic susceptibility. However,its specific mechanism is not clear and needs further study in the future.
作者
赵红兵
张春雨
宋青
张英
ZHAO Hongbing;ZHANG Chunyu;SONG Qing;ZHANG Ying(Department of Liver Disease,Hohhot Mongolian Medical Hospital of Traditional Chinese Medicine,Hohhot 010050,China)
出处
《医学综述》
2018年第15期2966-2969,2974,共5页
Medical Recapitulate
