摘要
目的观察外科手术对心脏瓣膜疾病致心脏功能不全患者血浆地高辛浓度变化的影响。方法采用超声心动评价术前、术后心脏功能。收集21例心脏瓣膜疾病患者,其中二尖瓣狭窄(MS)6例、二尖瓣关闭不全(MI)4例、主动脉瓣狭窄(AS)4例、主动脉瓣关闭不全(AI)4例、三尖瓣返流(TR)1例和二尖瓣狭窄合并关闭不全(MI+S)2例。采用酶放大免疫检测技术进行术前、术后稳态地高辛血药浓度监测。结果手术前后患者心脏左室舒张末期内径变化较大(P<0.05);相同给药剂量下,手术前后患者血浆地高辛浓度差异存在统计学意义(P<0.05)。结论术后患者血流动力学的改变明显影响体内地高辛药动学参数变化。
Objective To compare the effect of surgical treatment on digoxin concentration of cardiac insufficiency patient with valular heart disease. Methods Preoperative and postoperative cardiac function were evaluated by echocardiogram. 21 cases with cardiac insufficiency were obtained to study the surgical treatment,including MS（ 6）,MI（ 4）,AS（ 4）,AI（ 4）,TR（ 1） and MI ＋ S（ 2）. The plasma concentration of stable digoxin after operation was monitored by the enzyme amplification immunoassay. Results There was significant difference in left ventricular end-diastolic diameter before and after operation. The difference of plasma digoxin concentration before and after the operation was statistically significant under the same dosage. Conclusion Changes in hemodynamics with surgical treatment caused the changes of the pharmacokinetic parameters of digoxin.
作者
刘旭东
席云飞
杨剑
张斌
王云
LIU Xudong;XI Yunfei;YANG Jian;ZHANG Bin;WANG Yun(Department of Cardiovascular Surgery,General Hospital of Ningxia Medical University,Yinchuan 750004,Chin;Department of Pharmacy,General Hospital of Ningxia Medical University,Yin-chuan 750004,China)
出处
《宁夏医学杂志》
CAS
2018年第7期627-629,共3页
Ningxia Medical Journal
基金
宁夏医科大学校级科研项目(XM201431)
