摘要
Wnt/β-catenin信号通路和核因子κB（nuclear factor kappa B,NF-κB）信号通路都是相对保守的信号通路,贯穿哺乳类动物的一生并可以调节很多生物学进程。研究显示,Wnt/β-catenin通路与NF-κB通路之间存在交互作用,且共同参与多方面的调控。创面愈合是一个复杂而有序的过程,是涉及炎性细胞、细胞外基质和细胞因子等多种因素的级联反应。
Both Wnt/β-catenin and NF-κB signaling pathways are conserved pathways that regulate a variety of biological processes throughout the development and adult lifetime of mammals. Recent findings suggest that the 2 signaling pathways can cross-regulate each other. Several studies show that there are both positive and negative regulations between the 2 pathways. Some major components are involved in the cross-regulation of the 2 pathways such as Wnt proteins,DKK1,E-cadherin,GSK-3β,IKKs/IκB and so on. By reviewing the literature,we conjecture that the crosstalk between the 2 pathways regulate the wound healing process by intervening in the inflammation,fibroblast and angiogenesis,but the concrete mechanism is still unknown.
作者
赵亚男
刘明
魏建梁
张玉冬
王彬
张玥
王冠
ZHAO Ya-nan;LIU Ming;WEI Jian-liang;ZHANG Yu-dong;WANG Bin;ZHANG Yue;WANG Guan(Department of Vascular Surgery;Base of Hypertension,The Affiliated Hospital of Shandong University ofTraditional Chinese Medicine,Jinan 250014,China.)
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2018年第7期1339-1344,共6页
Chinese Journal of Pathophysiology
基金
山东省自然科学基金资助项目(No.ZR2017MH038)
