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氟哌噻吨美利曲辛对反流性食管炎伴焦虑患者负性情绪及黏膜愈合的影响 被引量:4

Effect of Flupentixol and Melitracen on Negative Emotion and Mucosal Healing in Patients with Reflux Esophagitis Complicated with Anxiety
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摘要 目的探讨氟哌噻吨美利曲辛对反流性食管炎伴焦虑患者负性情绪及黏膜愈合的影响。方法选择医院2014年3月至2016年11月收治的患者98例,根据治疗方法的不同分为对照组及观察组,各49例。两组患者均口服兰索拉唑及莫沙必利,观察组患者加服氟哌噻吨美利曲辛片。两组患者均治疗8周。结果治疗后,两组患者耐信量表(RDQ)灼痛感、反酸、烧心、嗳气等症状程度及频次评分均较治疗前明显下降(P<0.05),且观察组下降更显著(P<0.05);治疗后,两组患者洛杉矶内镜分级标准评价中食管黏膜评分、焦虑自评量表(SAS)及抑郁自评量表(SDS)负性情绪评分均较治疗前显著下降(P<0.05),且观察组负性情绪评分下降更显著(P<0.05),治疗后两组患者食管黏膜评分无显著差异(P>0.05);治疗后,两组患者食管括约肌压力(LES)与治疗前相比均升高,各类反流时间百分比均降低(P<0.05),且观察组各项反流时间百分比降低更显著(P<0.05),但组间LES比较无显著差异(P>0.05)。结论氟哌噻吨美利曲辛片治疗伴有焦虑症状的反流性食管炎疗效肯定,可减轻反流性食管炎相关不适症状,缩短反流时间百分比,并改善负性情绪,提高食管括约肌压力,值得临床推广。 Objective To investigate the effect of flupentixol and melitracen on the negative emotions and mucosal healing in patients with reflux esophagitis complicated with anxiety. Methods Totally 98 patients with reflux esophagitis complicated with anxiety admitted to our hospital from March 2014 to November 2016 were selected and divided into the control group and the observation group according to the different treatment methods,49 cases in each group. The two groups were given lansoprazole and mosapride,on this basis,the observation group were given Flupentixol and Melitracen Tablets. The two groups were treated for 8 weeks. Results After treatment,the severity and frequency of symptoms such as burning sensation,acid reflux,heartburn,belching and so on in the reliability scale( RDQ) in the two groups were significantly decreased than those before treatment( P〈0. 05),and the decrease in the observation group was more significant( P〈0. 05). After treatment,the scores of esophageal mucosa in Los Angeles endoscopy grading scale and negative emotion in self-rating anxiety scale( SAS) and self-rating depression scale( SDS) were significantly decreased in the two groups( P〈0. 05),and the score of negative emotion in the observation group was significantly lower than that of the control group( P〈0. 05),but there was no significant difference in the scores of esophageal mucosa between the two groups after treatment( P〈0. 05).After treatment,the lower esophageal sphincter( LES) in the two groups were significantly increased compared with those before treatment,and the percentages of various types of reflux time were significantly lower than those before treatment( P〈0. 05),and the percentage of reflux time in the observation group was significantly lower than that in the control group( P〈0. 05),but there was no significant difference in the LES between the two groups( P〈0. 05). Conclusion Flupentixol and Melitracen Tablets have certain clinical effect on patients
作者 周翔禹 李旭 王叶茂 雷蕾 贺建华 黄进启 Zhou Xiangyu;Li Xu;Wang Yemao;Lei Lei;He Jianhua;Huang Jinqi(Department of Gastroenterology,Central Hospital of Enshi Tujia and Miao Autonomous Prefecture,Enshi,Hubei,China 44500)
出处 《中国药业》 CAS 2018年第14期67-69,共3页 China Pharmaceuticals
关键词 反流性食管炎 兰索拉唑 氟哌噻吨美利曲辛片 负性情绪 黏膜愈合 reflux esophagitis lansoprazole Flupentixol and Melitracen Tablets negative emotions mucosal healing
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