摘要
目的探究前列腺癌相关基因4(PAGE4)在前列腺癌中的表达及其与预后的关系。方法以前列腺癌组织(Tum)及癌旁正常组织(Non-tum)标本85例作为研究对象,应用免疫组织化学分析的方法,检测癌组织中PAGE4蛋白表达情况,并分析其表达与临床病理参数及患者预后的关系。结果在前列腺癌患者癌组织中PAGE4表达阳性率为92.94%,显著高于癌旁正常组织中表达阳性率18.82%(χ~2=94.699,P<0.001)。PAGE4表达水平与患者年龄、血清PSA水平无关。PAGE4高表达率在Gleason分级为2~4、5~7、8~10中分别为47.37%、63.89%、90.91%,三者之间差异有统计学意义(χ~2=7.132,P=0.028)。PAGE4高表达率在临床分期T1、T2、T3、T4中分别为25.00%、45.83%、66.67%、78.26%,四者之间差异有统计学意义(χ~2=9.841,P=0.020)。PAGE4高表达率在有淋巴结转移中为20.00%,显著低于无淋巴结转移的88.00%(χ~2=39.667,P<0.001)。PAGE4高表达率在远处转移患者中为20.83%,显著低于无远处转移患者的75.41%,差异有统计学意义(χ~2=21.376,P<0.001)。结论前列腺癌组织中PAGE4蛋白高表达与患者Gleason分级及临床分期有关,低表达与淋巴结转移及肿瘤远处转移有关,高表达与患者预后不良有关,可作为前列腺癌预后判断潜在的生物标志物。
Objective To investigate the expression of prostate-associated gene 4（PAGE4）in prostate cancer and its relationship with prognosis. Methods A total of 85 cases of prostate cancer tissue（Tum）and non-tumble tissue（Non-tum）were studied.Immunohistochemistry was used to detect the expression of PAGE4 protein in cancer tissues.The relationship between the expression of PAGE4 and clinicopathological parameters and prognosis were also analyzed. Results The positive rate of PAGE4 expression in cancer tissues of prostate cancer patients was 92.94 % which was significantly higher than that of adjacent normal tissues 18.82%（χ^2=94.699,P〈0.001）.PAGE4 expression level had no correlation with age and serum PSA level of patients.PAGE4 high expression rate was 47.37%,63.89%and 90.91%respectively in Gleason grade2-4,5-7 and 8-10,and the differences among them were statistically significant（χ^2=7.132,P =0.028）.The high expression rate of PAGE4 in clinical stages T1,T2,T3 and T4 was 25.00%,45.83%,66.67% and78.26%respectively,and the differences among them were statistically significant（χ^2=9.841,P =0.020）.The high expression rate of PAGE4 in patients with lymph node metastasis was 20.00% which was significantly lower than that in patients without lymph node metastasis 88.00%（χ^2=39.667,P〈0.001）,and the high expression rate of PAGE4 in patients with distant metastasis was 20.23% which was significantly lower than that in patients without distant metastasis 75.41%（χ^2=21.376,P〈0.001）,and the above two differences were all statistically significant. Conclusion The high expression of PAGE4 protein in prostate cancer is related to the Gleason grading and clinical stage,and the low expression of it is related to lymph node metastasis and distant metastasis of tumor.The high expression of PAGE4 is also related to the poor prognosis of patients with prostate cancer and it can be used as a possible biomarker of prostate cancer prognosis.
作者
孟冬冬
吴军
黄群
Meng Dongdong;Wu Jun;Huang Qun(Department of Urology Surgery,Affiliated Hospital of Youjiang Medical University for Nationalities,Baise533000,Guangxi,Chin)
出处
《右江民族医学院学报》
2018年第3期227-229,253,共4页
Journal of Youjiang Medical University for Nationalities
