摘要
目的:探讨多囊卵巢综合征(polycystic ovary syndrome,PCOS)患者血清抗苗勒管激素(anti-Müllerian hormone,AMH)水平与肥胖、胰岛素抵抗(insulin resistance,IR)程度的相关性。方法:选择在我院生殖中心就诊的139名PCOS患者为研究组,并以月经周期正常、因输卵管因素或男性因素导致不孕者48名作为对照组。检测和比较PCOS患者的血清AMH、性激素水平及代谢指标,分析血清AMH水平与PCOS患者肥胖、胰岛素抵抗程度的关系。结果:PCOS组患者体质量指数(body mass index,BMI)、黄体生成素(luteinizing hormone,LH)、睾酮(testosterone,T)、垂体泌乳素(pituitary prolactin PRL)、空腹血糖(fasting plasma glucose,FPG)、空腹胰岛素(fasting insulin,FINS)、稳态模型胰岛素抵抗指数(homenostasis models assessment-insulin resistance index,HOMA-IR)的水平均显著高于对照组(P<0.05),PCOS组和对照组年龄、卵泡刺激素(follicle stimulating hormone,FSH)比较差异无统计学意义(P>0.05)。PCOS各表型组的血清AMH浓度、LH/FSH比值均明显高于对照组(P<0.05)。肥胖组患者的AMH浓度低于正常体重组,BMI、FPG、FINS、HOMA-IR、甘油三脂(triglycerides,TG)水平均高于正常体重组,LH、LH/FSH、高密度脂蛋白(high density lipoprotein,HDL-C)水平均低于正常体重组(P<0.05)。高HOMA-IR组患者的血清AMH浓度、LH、LH/FSH水平均明显低于低HOMA-IR组,BMI、T、FPG、FINS、TG、低密度脂蛋白(low density lipoprotein,LDL-C)水平均高于低HOMA-IR组(P<0.05)。PCOS患者血清AMH浓度和BMI及HOMA-IR均存在显著负相关。结论:PCOS患者血清的AMH水平较对照组明显升高,与其肥胖、胰岛素抵抗(IR)程度呈显著负相关。
Objective： To investigate the correlation of anti-mullerian hormone（AMH） level with the severity of obesity,insulin resistance（IR） in polycystic ovary syndrome（PCOS）.Methods： 139 cases of PCOS patients who admitted in the reproductive center of our hospital were selected as the study group,and the patients with normal menstrual cycle,fallopian tube factor or male factors were selected as the control group.The serum AMH,sex hormone levels and metabolic index of PCOS patients were detected and compared,and the relationship between serum AMH level and the severity of obesity and insulin resistance in patients with PCOS were analyzed.Results： The body mass index（BMI） of study group（body mass index,BMI）,luteinizing hormone,luteinizing hormone,LH）,testosterone（testosterone,T）,pituitary prolactin（pituitary prolactin PRL）,fasting glucose,fasting plasma glucose,FPG）,fasting insulin,fasting insulin and FINS）,steady-state model of insulin resistance index（homeostasis models assessment-insulin to hold the index,HOMA-IR） levels were significantly higher than those of the control group（P〈0.05）,and the age,FSH（follicle stimulating hormone,FSH）showed no statistically significant difference between two groups（P〉0.05）.The serum AMH concentration and LH/FSH ratio of each phenotype group were significantly higher than those in the control group（P〈0.05）.The AMH concentration was lower in the obese patients than those patients with normal body weight,while the BMI,FPG,FINS,HOMA-IR,triglycerides（triglycerides,TG） levels were higher than in the normal weight group,the LH,LH/FSH,high-density lipoprotein cholesterol（HDL-C） levels were lower than those of the normal weight group（P〈0.05）.The serum AMH concentration,LH,and FSH levels of patients with high HOMA-IR group were significantly lower than those with lower HOMA-IR,and the levels of BMI,T,FPG,FINS,TG,and low-density lipoprotein（LDL-C） were all higher than those with lower HOMA-IR（P〈0.05）.There w
作者
周密
丁旭
宋晖
滑玮
黄艳红
ZHOU Mi;DING Xu;SONG Hui;HUA Wei;HUANG Yan-hong(Reproductive Medical Center,Department of Obstetrics ＆ Gynaecology,Xijing Hospital,The Air Force Military Medical University,Xi＇an,Shaanxi,710032,China)
出处
《现代生物医学进展》
CAS
2018年第10期1916-1921,共6页
Progress in Modern Biomedicine
基金
陕西省社会发展科技攻关项目(2015SF121)
西京医院临床新技术新业务项目(XJGX15Y57)
关键词
多囊卵巢综合征
抗苗勒管激素
肥胖
胰岛素抵抗
Polycystic ovary syndrome
Anti-Mu llerian hormone
Obesity
Insulin resistance
