摘要
目的分析不同临床病理特征的卵巢恶性生殖细胞肿瘤(MOGCTs)患者预后。方法选取监测、流行病学和结果数据库(SEER)中MOGCTs的患者的临床病理数据共2 801例进行分析。用Kaplan-Meier法绘出生存曲线,log-rank检验单因素分析预后影响因素,Cox回归模型进行多因素分析。结果单因素分析显示:MOGCTs预后与年龄(c^2=93.119,P=0.000)、种族(c^2=12.894,P=0.002)、病理类型(c^2=316.287,P=0.000)、肿瘤分化(c^2=27.476,P=0.000)、国际妇产科联盟(FIGO)分期(c^2=187.837,P=0.000)、肿瘤位置(c^2=36.959,P=0.000)、肿瘤大小(c^2=319.981,P=0.000)、淋巴结转移(c^2=20.849,P=0.000)和手术方式(c^2=170.370,P=0.000)等有关。多因素分析显示MOGCTs预后与FIGO分期(P=0.004,95%CI=1.204~2.603)、病理类型(P=0.010,95%CI=1.109~2.144)、发病年龄(P=0.009,95%CI=1.340~7.584)有关。结论 FIGO分期、病理类型和发病年龄高是MOGCTs其预后的独立危险因素。
Objective To analyse the prognosis of malignant germ cell tumor of ovary（MOGCTs） with different clinicopathological features. Methods The clinical and pathological data of 2 801 patients with MOGCTs in SEER database were analyzed. Survival curve was plotted by Kaplan-Meier method. Univariate analysis was performed by log-rank test. Cox regression model was used for multivariate analysis. Results Univariate analysis showed that the prognosis was associated with the age of diagnosis（c2=93.119, P=0.000）, race（c2=12.894, P=0.002）, pathological types（c2=316.287, P=0.000）, pathological differentiation（c2=27.476, P=0.000）, International Federation of Gynecology and Obstetrics（FIGO） stage（c2=187.837, P=0.000）, tumor location（c2=36.959, P=0.000）, tumor size（c2=319.981, P=0.000）, lymphatic metastasis（c2=20.849, P=0.000） and scope of operation（c2=170.370, P=0.000）. Multivariate analysis showed that the prognosis was associated with FIGO stage（P=0.004, 95% CI=1.204-2.603）, pathological types（P=0.010, 95% CI=1.109-2.144）, and the age of diagnosis（P=0.009, 95% CI=1.340-7.584）. Conclusion FIGO stage, pathological type and age are independent risk factors for prognosis of MOGCTs. Therefore, it is feasible for young women to perform the operation of preserving reproductive function.
作者
纪逸萱
盛菲
马妍
丁海遐
章青
李文
Ji Yixuan;Sheng Fei;Ma Yan;Ding Haixia;Zhang Qing;Li Wen(Reproductive Medicine Center,Changzheng Hospital,Second Military Medical University,Shanghai 200011,China)
出处
《中华生殖与避孕杂志》
CAS
CSCD
北大核心
2018年第5期375-379,共5页
Chinese Journal of Reproduction and Contraception
基金
国家自然科学基金项目(81272213)~~
