摘要
目的比较天南星科的3种有毒中药半夏、天南星、白附子的生品和制品的急性毒性。方法按Bliss法设计实验,小鼠分别单次腹腔注射半夏、天南星、白附子的生品、制品水提液,连续观察14 d,记录小鼠的毒性反应,以急性死亡率为指标,测定半夏、天南星、白附子的LD_(50)。结果生半夏、生天南星、生白附子腹腔注射的LD_(50)分别为5.381 g/kg、21.508 g/kg、39.311 g/kg;而半夏、天南星、白附子的炮制品腹腔注射均无明显毒性表现。结论天南星科3种有毒中药半夏、天南星、白附子生品腹腔注射有明显急性毒性,其中又以生半夏毒性最强,但3种有毒中药经过炮制后毒性明显降低。
Objective To study the acute toxicity of three Araceae toxic Chinese herbs and their processed products,including pinelliae rhizoma,arisaematis rhizoma and typhonii rhizome. Methods The experiments were designed according to Bliss algorithm,and mice were injected intraperitoneally with aqueous extract of Chinese herbs,and continuously observed for 14 days. The LD50 of pinelliae rhizoma,arisaematis rhizoma and typhonii rhizoma were calculated with acute mortality. Results The LD50 of pinelliae rhizoma,arisaematis rhizoma and typhonii rhizoma were 5. 381 g/kg, 21. 508 g/kg, 39. 311 g/kg, respectively, but their processed products had no significant toxicity. Conclusion Three Araceae toxic Chinese herbs including pinelliae rhizoma,arisaematis rhizoma and typhonii rhizoma have significant acute toxicity,among which the toxicity of pinelliae rhizoma is the strongest, but the toxin could be reduced significantly after being processed.
作者
吴紫君
冯碧川
沈志滨
杨超燕
陈嘉洛
彭昌杰
吴志坚
李书渊
陈艳芬
WU Zijun;FENG Bichuan;SHEN Zhibin;YANG Chaoyan;CHEN Jialuo;PENG Changjie;WU Zhijian;LI Shuyuan;CHEN Yanfen(School of Traditional Chinese Medicine Guangdong Pharmaceutical University Guangzhou 510006 China;Guangzhou Chinese Herbal Medicine Factory Guangzhou 510360 China)
出处
《广东药科大学学报》
CAS
2018年第3期312-315,共4页
Journal of Guangdong Pharmaceutical University
基金
广东药科大学2015级省级大学生创新创业训练计划项目(201510573034)
国家中医药管理局中医药行业专项(201507004)
关键词
半夏
天南星
白附子
急性毒性
LD50
pinelliae
rhizoma arisaematis
rhizoma typhonii
rhizoma acute toxicity LD50
