摘要
目的:对全身麻醉气管插管患者应用右美托咪啶预防心血管反应的效果进行探讨。方法:选取2017年1-5月笔者所在医院收治的择期手术患者40例进行研究,所有患者均行全身麻醉,随机将患者分为观察组与对照组,各20例,对照组麻醉诱导前给予静脉泵注生理盐水,观察组麻醉诱导前给予静脉泵注右美托咪啶,两组麻醉诱导用药均为咪唑安定、芬太尼、维库溴铵及依托咪酯。对两组患者不同时间段SBP、DBP及HR变化情况进行对比。结果:与给药前、给药后及插管前对比,两组BP及HR均在插管时、插管后1 min时有不同程度升高,且插管时、插管后1 min时观察组患者BP、HR均明显低于对照组,差异均有统计学意义(P<0.05);给药后、插管前及插管后3、5 min时,观察组HR均较给药前明显下降,差异均有统计学意义(P<0.05)。结论:在全麻气管插管患者中应用右美托咪啶,可有效预防心血管反应,稳定血流动力学,值得推广应用。
Objective：To discuss the clinical effect of Dexmetidine in the prevention of cardiovascular response in patients undergoing general anesthesia.Method：A total of 40 patients undergoing elective surgery in the author,s hospital from January to May 2017 was conducted,all patients with general anesthesia,all patients were randomly divided into observation group and control group,with 20 cases in each group,the control group was given intravenous infusion of saline before anesthesia induction,the observation group was given intravenous injection of Dexmetidine before anesthesia induction,Midazolam,Fentanyl,Vecuronium and Etomidate were used to induce anesthesia in both groups.The changes of SBP,DBP and HR in two groups of patients at different time periods were compared.Result：Compared with those before administration,after administration and before intubation,BP and HR in both groups increased in varying degrees during intubation and at 1 minite after intubation,the differences were statistically significant（P〈0.05）.HR in observation group was significantly lower than that before administration, before intubation and 3 minites after intubation,the differences were statistically significant（P〈0.05）.Conclusion：The application of dexmetidine in patients with endotracheal intubation under general anesthesia can effectively prevent cardiovascular reaction and stabilize hemodynamics.
作者
王文法
杨玲梅
赵云卫
杨涛
叶芹芬
WANG Wenfa,YANG Lingmei,ZHAO Yunwei(Chuxiong People＇s Hospital, Chuxiong 675000, Chin)
出处
《中外医学研究》
2018年第16期103-105,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
全身麻醉
气管插管
心血管反应
右美托咪啶
General anesthesia
Endotracheal intuhation
Cardiovascular response
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