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右旋美托咪啶预给量对全麻诱导气管插管中心血管反应的影响 被引量:1

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摘要 目的:观察右旋美托咪啶预给量对全麻诱导中气管插管所诱发的心血管反应的影响。方法:44例全麻手术患者随机分为右旋美托咪啶组22例,对照组22例。右旋美托咪啶组应用右旋美托咪啶1μg/kg,15 min泵完后立即行麻醉诱导气管插管,对照组直接行麻醉诱导气管插管。记录2组患者在全麻诱导前、全麻诱导后、气管插管后1、3、5 min时的SBP、DBP、HR、MAP、SPO2。结果:诱导后右旋美托咪啶组与对照组的收缩压、舒张压与诱导前比较明显降低(P<0.05));插管后右旋美托咪啶组、对照组的收缩压较诱导后都升高(P<0.05)。插管后3min右旋美托咪啶组的收缩压和舒张压均比对照组低(P<0.05)。右旋美托咪啶组在给予右旋美托咪啶后与对照组相比,心率波动幅度明显没有对照组大,各时点值均低于对照组(P<0.05)。对照组诱导后平均动脉压明显比诱导前降低,但在插管后5 mih内明显增高,增高幅度在20%以上(P<0.05),右旋美托咪啶组在整个诱导过程中变化不大,插管后5 min内与插管前相比无明显增高,与对照组相比,变化幅度明显没有对照组大,且各时点值均低于对照组(P<0.05)。结论:预先结予一定量的右旋美托咪啶能有效的抑制全麻气管插管时所诱发的心血管反应,稳定患者的血流动力学,其操作方法安全、易行,疗效确切,是一种很有前途的麻醉辅助药。
作者 潘英芳
出处 《赣南医学院学报》 2012年第4期563-564,共2页 JOURNAL OF GANNAN MEDICAL UNIVERSITY
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