摘要
目的探讨多囊卵巢综合征(PCOS)合并亚临床甲状腺功能减退(SCH)的患者胰岛素抵抗及脂代谢特征。方法选择2015年9月~2016年10月在首都医科大学附属北京妇产医院内分泌门诊就诊的200例PCOS患者分为两组:41例合并亚临床甲减的研究组(SCH-PCOS组)和159例甲状腺功能正常的对照组(EU-PCOS组);比较两组的临床特征、性激素水平、空腹胰岛素水平及血脂参数。结果 SCH-PCOS组体重指数(BMI)、空腹胰岛素(FIN)及稳态模型评估的胰岛素抵抗指数(HOMA-IR)均大于EU-PCOS组,差异有统计学意义(P<0.05)。血脂参数轻度异常,但差异无统计学意义(P>0.05)。结论 PCOS合并SCH比甲状腺功能正常的PCOS患者存在更严重的肥胖及胰岛素抵抗。
Objective To evaluate the characteristics of insulin resistance and lipid metabolism of PCOS patients with SCH. Methods A total of 200 patients with PCOS were recruited at the Department of Endocrinology, Beijing Obstetrics and Gynecology Hospital from September 2015 to October 2016. And they were divided into two groups： 41 cases of subclinical hypothyroidism（SCH-PCOS group） as study group and 159 cases of normal thyroid function（EU-PCOS group） as control group. The clinical features, sex hormone levels, fasting insulin levels and serum lipids between the groups were investigated. Results Body mass index（BMI）, fasting insulin（FIN） and homeostatic model assessment-insulin resistance（HOMA-IR） were higher than those in SCH-PCOS group（P〈0.05）. Lipid metabolism was slightly abnormal, but the difference was not statistically significant（P〉0.05）. Conclusion The analysis indicates that PCOS complicated with SCH patients have more severe obesity and insulin resistance than those with normal thyroid functions.
作者
殷冬梅
阮祥燕
田玄玄
卢永军
YIN Dongmei;RUAN Xiangyan;TIAN Xuanxuan;LU Yongjun(Department of Endocrinology,Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing100026,China;Department of Obstetrics and Gynecology,Tongzhou Maternal and Child Health Hospital of Beijing,Beijing 101101,China)
出处
《中国医药导报》
CAS
2018年第17期68-71,共4页
China Medical Herald
基金
首都卫生发展科研专项项目(首发2016-2-2113)
北京市医院管理局临床技术创新项目(XMLX201710)
国家外国专家局北京市引进国外技术
管理人才项目(2017041900004)
