摘要
目的探讨养血清脑颗粒联合右佐匹克隆片治疗卒中后睡眠障碍的临床疗效。方法收集卒中后睡眠障碍患者120例,随机分为观察组及对照组,每组各60例。2组患者均给予相同的基础治疗,对照组同时给予口服右佐匹克隆片治疗,观察组在对照组基础上加用养血清脑颗粒口服,每2周为一疗程,均治疗6周。对2组治疗前,治疗后2、4、6周睡眠障碍[采用匹兹堡睡眠质量指数问卷(Pittsburgh sleep quality index,PSQI)]及神经功能缺损[采用中国脑卒中临床神经功能缺损程度评分量表(Chinese stroke scale,CSS)]情况进行评价,比较2组疗效。结果观察组总有效率为86.67%,明显高于对照组的63.33%(P<0.05);治疗后2、4、6周,观察组、对照组睡眠障碍、神经功能缺损均较治疗前改善,但观察组比对照组改善效果更佳,且随疗程延长,改善越明显(均P<0.05)。结论单用右佐匹克隆片可有效改善卒中后睡眠障碍及神经功能缺损,且随疗程延长,改善越明显,联合使用养血清脑颗粒疗效更佳。
Objective To investigate the clinical efficacy of Cerebralcare Granule combined with eszopiclone tablets in the treatment of post-stroke sleep disorder.Methods A total of 120 patients were given the basic therapy for post-stroke sleep disorder.In addition,these patients were orally treated with eszopiclone tablets alone（control group,n=60）or in combination with Cerebralcare Granule（observation group,n=60）for 6 weeks（3 courses of treatment）.Sleep disorder and neurologic impairment were respectively evaluated using Pittsburgh Sleep Quality Index（PSQI）and Chinese Stroke Scale（CSS）before and 2,4 and 6 weeks after treatment.The clinical efficacy was compared between the two groups.Results The total effective rate in observation group（86.67%）was significantly higher than that in control group（63.33%）（P〈0.05）.At 2,4 and 6 weeks after treatment,sleep disorder and neurologic impairment were improved in both groups,and the improvement in observation group was more obvious than that in control group with the prolonged period of treatment（P〈0.05）.Conclusion The teatment with eszopiclone tablets,especially in combination with Cerebralcare Granule,can effective relieve post-stroke sleep disorder and neurologic impairment in a time dependent manner.
作者
何敏
刘志强
刘艳龙
朱晓钢
HE Min;LIU Zhi-qiang;LIU Yan-long;ZHU Xiao-gang(a.The Second Department of Neurolog;b.Department of of Anesthesiology,Jiangxi Provincial People’s Hospital,Nanchang 330006,Chin)
出处
《实用临床医学（江西）》
CAS
2018年第4期10-13,22,共5页
Practical Clinical Medicine
