摘要
目的探讨肝动脉化疗栓塞联合射频消融治疗原发性肝癌的临床疗效及对血清学指标的影响。方法选取2014年1月~2016年1月在我院治疗的原发性肝癌患者共50例,分为观察组与对照组。两组患者均予以肝动脉化疗栓塞术,观察组加用射频消融术,观察并比较两组的治疗效果,治疗前后分别检测甲胎蛋白(AFP)、糖类抗原199(CA199)及谷氨酰转肽酶(GGT),并观察两组2年无瘤生存率及不良反应。结果治疗后4周,两组血清AFP、CA199、GGT水平均较前明显下降(P<0.05或P<0.01),且观察组下降幅度更明显(P<0.05);同时观察组治疗总有效率高于对照组(P<0.05);观察组2年内无瘤生存率高于对照组(P<0.05);两组不良反应率比较无统计学差异(P>0.05)。结论肝动脉化疗栓塞联合射频消融治疗原发性肝癌疗效显著,能降低血清AFP、CA199及GGT水平,提高2年内无瘤生存率,安全性较好。
Objective To investigate the clinical effectiveness of treatment combining hepatic arterial chemoembolization（HACE） and radiofrequency ablation and its influence on serum markers in patients with primary liver cancer.Methods 50 patients with primary liver cancer in our hospital from January 2014 to January 2016 were selected and divided into observation group and control group. Patients in both of two groups were treated with HACE while patients in observation group were treated with additional radiofrequency ablation. Effectiveness of two groups was observed and compared. The levels of alpha fetoprotein（AFP）, carbohydrate antigen 199（CA199） and glutamyl transpeptidase（GGT）before and after treatment were detected. 2-year tumor-free survival and adverse reaction in two groups were observed.Results 4 weeks after treatment, levels of serum AFP, CA199 and GGT in two groups decreased significantly when compared with those before treatment（P〈0.05 or P〈0.01） and those in observation group decreased more significantly（P〈0.05）. Total effective rate of treatment in observation group was higher than that in control group（P〈0.05）. The rate of 2-year tumor-free survival in observation group was higher than that in control group（P〈0.05）. The incidence of adverse reaction was not statistically different between two groups（P〈0.05）. Conclusion Treatment combining HACE and radiofrequency ablation in patients with primary live cancer was effective. It could reduce the levels of serum AFP,CA199 and GGT and improve the rate of 2-year tumor-free survival safely.
作者
张玉惠
张伟忠
ZHANG Yuhui;ZHANG Weizhong(Department of Hepatobiliary Surgery,Zhoushan Hospital in Zhejiang Province,Zhoushan 316002,China)
出处
《中国现代医生》
2018年第14期14-17,共4页
China Modern Doctor
基金
浙江省科技计划项目(2015C33271)
关键词
原发性肝癌
肝动脉化疗栓塞
射频消融
血清学指标
Primary liver cancer
Hepatic arterial chemoembolizafion
Radiofrequency ablation
Serum marker
