摘要
目的:探讨鼻内镜手术联合布地奈德鼻喷雾剂治疗鼻息肉的临床疗效及对患者生活质量的影响。方法:鼻息肉患者共132例,按照数字表法随机分为对照组(n=66)和研究组(n=66),对照组给予鼻内镜手术治疗,研究组给予鼻内镜手术联合布地奈德鼻喷雾剂治疗,对比两组患者在治疗后的临床效果、VAS评分(疼痛评分)、LKES评分(内镜评分)、治疗前后鼻黏膜中VEGF、GM-CSF、IL-1β、IFN-γ的表达水平以及治疗前后患者的生活质量。结果:研究组患者的治疗有效率明显高于对照组患者(P<0.05);研究组患者的VAS评分明显低于对照组患者(P<0.05);研究组患者的LKES评分明显低于对照组(P<0.05);治疗前,两组患者鼻黏膜中的VEGF、GM-CSF、IL-1β、IFN-γ的表达水平无统计学差异(P>0.05),治疗后,研究组患者鼻黏膜中的VEGF、GMCSF、IL-1β、IFN-γ的表达水平明显低于对照组患者(P<0.05);治疗前,两组患者的生活质量评分无统计学差异(P>0.05),治疗后,研究组患者的生活质量明显高于对照组患者(P<0.05)。结论:鼻内镜手术联合布地奈德鼻喷雾剂治疗的临床疗效明显,安全性高,对患者的生活质量具有显著的改善作用,值得在临床上进一步推广应用。
Objective：To investigate the clinical efficacy of nasal endoscopic surgery combined with budesonide nasal inhalation in the treatment of nasal polyps and its impact on the quality of life of patients.Methods：A total of 132 patients with nasal polyps treated in our hospital in March September 2015-2018 were selected as the research subjects.They were randomly divided into the control group（n=66）and the study group（n=66）according to the digital table method.The control group was treated with nasal endoscopy,and the study group was treated with nasal endoscopic surgery combined with budesonide nasal atomization inhalation treatment.Compared to the two groups,the clinical effect,the VAS score（pain score）,the LKES score（endoscopy score）,the expression level of VEGF,GM-CSF,IL-1 beta,IFN-gamma in the nasal mucosa before and after treatment,and the quality of life of the patients before and after treatment were compared.Results：After treatment,the treatment and efficiency of the patients in the study group were significantly higher than those of the control group（P〈0.05）.Before treatment,there was no significant difference in the VAS score between the two groups.After the treatment,the VAS score of the patients in the study group was significantly lower than that of the control group（P 0.05）;the LKES score of the two groups was not significantly worse before the treatment.After treatment,the LKES score of the patients in the study group was significantly lower than that of the control group（P〈0.05）.Before treatment,the expression levels of VEGF,GM-CSF,IL-1 beta and IFN-gamma in the nasal mucosa of the two groups were not significantly different（P〈0.05）.After treatment,the expression level of VEGF,GM-CSF,IL-1 beta and IFN-gamma in the nasal mucosa of the study group was obvious.Lower than the control group（P〈0.05）;before treatment,the quality of life of the two groups had no significant difference（P〈0.05）.After treatment,the quality of life of the patients in the stu
作者
李雅琼
王新亮
袁浩展
王艳婷
姬敏干
Li Yaqiong;Wang Xinliang;Yuan Haozhan(First People＇s Hospital,Xianyang City,Shaanxi Province（Xianyang 712000)
出处
《陕西医学杂志》
CAS
2018年第7期858-861,共4页
Shaanxi Medical Journal
