摘要
目的探讨缺血修饰蛋白对肺炎合并心力衰竭新生儿心肌损害损伤程度及预后诊断中的临床意义。方法选取肺炎、肺炎合并心力衰竭及正常新生儿各60例,检测其血清缺血修饰蛋白(IMA)、c Tn I和CK-MB水平并进行比较。通过超声检测计算3组新生儿左心室Tei指数并进行比较。比较肺炎合并心力衰竭组新生儿IMA、c Tn I和CK-MB指标的阳性率。分析肺炎合并心力衰竭组新生儿IMA与c Tn I、CK-MB及左心室Tei指数的相关性。随访肺炎合并心力衰竭组新生儿,记录该组患儿死亡病例及心脏事件发生率,分析IMA水平与预后的关系。结果 3组患儿在IMA、c Tn I和CK-MB三个指标方面的差异均有统计学意义,肺炎合并心力衰竭组患儿上述3种指标均显著高于其余两组(P<0.05)。肺炎合并心力衰竭组新生儿IMA的检测阳性率最高,为88.33%(P<0.05)。肺炎合并心力衰竭组左心室Tei指数为0.42±0.11,显著高于其余两组(P<0.05)。肺炎合并心力衰竭组新生儿IMA与c Tn I、CK-MB及左心室Tei指数均呈显著正相关(r=0.81,r=0.73,r=0.69,P<0.05)。高IMA组患儿病死率及心脏事件发生率均显著高于中IMA组及低IMA组(P<0.05)。结论缺血修饰蛋白可作为肺炎合并心力衰竭新生儿心肌损害程度及预后判断的有效指标。
Objective To explore the clinical significance of ischemia modified albumin for the degree of myocardial damage and prognosis of neonates with pneumonia combined with heart failure.Methods Select 60 samples of neonates with pneumonia,neonates with pneumonia combined with heart failure,and normal neonates respectively,then detect and compare the level of ischemia modified protein（IMA）,c Tn I and CK-MB from the three groups neonates＇ serum.Calculate the left ventricular Tei index of three groups neonates by ultrasonic testing and compare.Compare the positive rates of IMA,c Tn I,and CK-MB in neonates with pneumonia combined with heart failure group.Analyze the correlation between IMA and c Tn I,CK-MB,and left ventricular Tei index in neonates with pneumonia combined with heart failure group.The incidence of death and cardiac events were recorded by follow-up visiting neonates with pneumonia combined with heart failure,and the relationship between IMA level and prognosis was analyzed.Results The differences in three indexes of IMA,c Tn I and CK-MB were statistically significant in the three groups,all of which were significantly higher in neonates with pneumonia combined with heart failure group than those in other two groups（P〈 0.05）.The positive rate of IMA in neonates with pneumonia combined with heart failure group was the highest 88.33%（P 〈0.05）.The left ventricular Tei index of the pneumonia combined with heart failure neonates group was 0.42 ± 0.11,which was significantly higher than the other two groups（P〈 0.05）.The IMA and c Tn I,CK-MB and left ventricular Tei index in pneumonia combined with heart failure neonates were all positively correlated（r= 0.81,r = 0.73,r = 0.69,P〈 0.05）.Both the mortality and cardiac events in the high IMA group were significantly higher than that in the mid-level IMA group and the low-level IMA group（P 〈0.05）.Conclusion The ischemic modified albumin can be used as an effective indicator for the degree of myocardial damage and prognosis of neona
作者
黄晗
卢红霞
Huang Han;Lu Hongxia(Zhengzhou Children＇s Hospital,Henan 450018,China)
出处
《医学研究杂志》
2018年第5期153-156,152,共5页
Journal of Medical Research
关键词
缺血修饰蛋白
肺炎
心力衰竭
新生儿
Isehemie modified albumin
Pneumonia
Heart failure
Neonatal
