摘要
肠道病毒71型(enterovirus 71,EV71)是导致手足口病(hand,foot and mouth disease,HFMD)重症和死亡病例的主要病原体。2015年我国研制成功世界上首批EV71疫苗,2016年疫苗通过批签发上市。EV71疫苗的研发成功为我国以及世界范围控制严重HFMD的暴发和流行提供了有效手段。然而疫苗上市后仍面临进一步大规模人群应用的效果和安全性观察,疫苗质控标准和规范的建立、完善,疫苗应用后人群中HFMD新的流行态势等研究课题。本文对近期EV71疫苗的研究进展和应用进行了综述。
Enterovirus 71（EV71） is a major pathogen of severe and dead cases of hand,foot and mouth disease（HFMD）. The first batch of EV71 vaccine was developed in China in 2015. In 2016,the vaccine came into the market through batch release. The development of EV71 vaccine provides an effective tool for control of the outbreak and epidemic of severe HFMD in China and the world. However,there are still a series of problems such as the effect and safety of the vaccine in large-scale clinical trials,establishment and improvement of standard for quality control of vaccine as well as new epidemic status of HFMD in humans. This paper reviews the progress in research and application of EV71 vaccine.
作者
苏瑶
高帆
吴星
姜崴
毛群颖
SU Yao;GAO Fan;WU Xing;JIANG Wei;MAO Qun-ying(Division of Hepatitis Virus Vaccines,National Institutes for Food and Drug Control,Beijing 100050,China)
出处
《中国生物制品学杂志》
CAS
CSCD
2018年第7期782-786,共5页
Chinese Journal of Biologicals
关键词
肠道病毒71型
手足口病
疫苗
Enterovirus 71(EV71）
Hand
foot and mouth disease(HFMD）
Vaccine
