摘要
目的探讨氨磺必利与利培酮治疗女性精神分裂症(SP)的疗效及不良反应。方法选取医院治疗的女性SP患者90例,随机分为两组,各45例。观察组给予氨磺必利治疗,对照组给予利培酮治疗。对比两组治疗效果及治疗前后体质指数、空腹血糖、胆固醇、三酰甘油以及PANSS评分变化,统计两组药物不良反应。结果观察组治疗总有效率(95.56%)高于对照组(75.56%)(P<0.05);治疗后,两组体质指数、胆固醇、三酰甘油均有升高,且观察组高于对照组(P<0.05);两组PANSS阳性症状和阴性症状评分均降低,且观察组低于对照组(P<0.05)。治疗期间,两组均出现恶心、嗜睡、便秘等不良反应,但观察组总发生率(8.89%)低于对照组(26.67%)(P<0.05)。结论氨磺必利治疗女性SP的疗效好于利培酮,且不良反应发生率低,值得临床推广使用,但是氨磺必利对脂代谢的影响大于利培酮,在治疗过程中,应该加强血脂的监测和控制。。
Objective To explore the efficacy and side effects of amisulpride and risperidone in the treatment of female schizophrenia （SP）. MeAods A total of 90 female SP patients admitted into our hospital were randomly divided into two groups （n= 45, respectively）. The observation group was treated with amisulpride, while the control group was treated with risperidone. The effects, changes of body mass index, fasting blood glucose, cholesterol, three acyl glycerol and PANSS score before and after the treatment between the two groups were compared and the adverse drug reactions in the two groups were statistically analyzed. Results The total effective rate of treatment in the observation group （95.56%） was higher than that in the control group （75.56%; P 〈 0.05）. After the treatment, the body mass index, cholesterol and three acyl glycerol increased in the two groups, and those in the observation group were higher than those in the control group （P 〈 0.05）; the PANSS positive symptoms and negative symptoms in the two groups decreased, and those in the observation group were lower than those in the control group （P 〈 0.05）. During the treatment, adverse reactions such as nausea, lethargy and constipation were found in the two groups, but the total incidence in the observation group （8.89%） was lower than that in the control group （26.67%） （P 〈 0.05）. Conclusion The effect of amisulpride in the treatment of female SP is better than that of risperidone, and the incidence of adverse reaction is low. It is worth popularizing in clinical practice. However, the effect of amisulpride on lipid metabolism is greater than that of risperidone. During the treatment, the monitoring and control of blood lipid should be strengthened.
作者
韩兴玲
王惠玲
Han Xingling;Wang Huiling(The Second Department of Psychology,Wuhan Youfu Hospital,Wuhan,Hubei,430023,China;3.Mental Health Center of Renmin Hospital of Wuhan University,Wuhan,Hubei,430060,China)
出处
《西南国防医药》
CAS
2018年第6期531-533,共3页
Medical Journal of National Defending Forces in Southwest China
