摘要
目的评价帕利哌酮和氨磺必利对首发未用药女性精神分裂症患者血清催乳素水平、体质量以及认知功能的影响。方法将90例女性首发未服药精神分裂症患者分为两组:帕利哌酮组45例患者采用口服帕利哌酮缓释片治疗,氨磺必利组45例患者通过口服氨磺必利治疗,两组均治疗12周。比较治疗前后两组患者的血清泌乳素水平、体重、阳性和阴性症状量表(PANSS)评分、韦氏成人量表(WMS-RS)评分以及精神分裂症认知功能成套测试(MCCB)评分。结果两组血清催乳素水平治疗后各周期较治疗前均有显著提高(P<0.05),治疗后两组比较差异无统计学意义(P>0.05);两组治疗后12周体重较治疗前都有显著增加(P<0.05),帕利哌酮组增加幅度低于氨磺必利组(P<0.05);两组治疗后12周PANSS评分较治疗前都有显著降低(P<0.05),但帕利哌酮组治疗后降低的幅度显著高于氨磺必利组(P<0.05)。结论帕利哌酮和氨磺必利都能导致患者血清催乳素和体质量增加,但是氨磺必利体重增加的幅度更大。两种药物都能显著改善精神分裂症患者认知功能障碍,但帕利哌酮的治疗效果优于氨磺必利。
Objective To evaluate and compare the effect of paliperidone and amisulpride on serum prolactin levels,body weight and cognitive function of female first-episode schizophrenia patients without medication. Methods 90 cases of female first-episode schizophrenia patients without medication were divided into two groups randomly ：the paliperidone group were treated with paliperidone extended release tablets for 12 weeks,while the amisulpride group were given amisulpride for 12 weeks. The serum prolactin levels,body weight,scores of PANSS,WMS-RS and MCCB were compared before and after treatment. Results Theserum prolactin levels of both groups after treatment in each cycle were all significantly increased than those before treatment（P〈0.05）,but the difference between the two groups had no statistical significance after treatment（P〈0.05）;The body weight of the two groups after 12 weeks of treatment were both significantly higher than those before treatment（P〈0.05）,the paliperidone group increased significantly lower than those in amisulpride group（P〈0.05）;The PANSS scores 12 weeks after treatment of the two groups were both significantly lower than those before treatment（P〈0.05）,But paliperidone group after treatment decreased more significantly than that of the amisulpride group（P〈0.05）. Conclusion Paliperidone and amisulpride can both increase the serum prolactin and body weight of female first-episode schizophrenia patients without medication,but amisulpride body mass weight increased more. The two drugs can significantly improve the cognitive impairment of schizophrenia patients,but paliperidone clinical effect is better than amisulpride.
作者
李娜
梁静
曹璇
李伟
张顺
郭建兵
LI Na;LIANG Jing;CAO Xuan(KaiLuan Mental Health Centre,TangShan 063000,China)
出处
《国际精神病学杂志》
2018年第4期597-599,607,共4页
Journal Of International Psychiatry
