摘要
目的探讨乳腺癌新辅助化疗前后MR扩散加权成像（DWI）表观扩散系数（ADC）值与Ki-67表达水平的相关性。方法回顾性分析54例行新辅助化疗的乳腺癌患者资料。患者于新辅助化疗前及化疗后均行DWI检查,并取得检查后病理组织测定Ki-67表达情况。对比新辅助化疗前后乳腺癌ADC值及Ki-67指数的差异,并分析新辅助化疗前后乳腺癌ADC值（ADC前、ADC后）、ADC变化值（△ADC）、ADC变化率（△ADC%）与Ki-67指数（Ki-67前、Ki-67后）、Ki-67变化值（△Ki-67）、Ki-67变化率（△Ki-67%）的相关性。结果新辅助化疗后乳腺癌ADC值较化疗前增高（P=0.000）,Ki-67指数较化疗前降低（P=0.007）。ADC前、ADC后、△ADC%与Ki-67前、Ki-67后、△Ki-67%无明显相关性（P=0.862、0.292、0.562）,△ADC与△Ki-67呈负相关（P=0.033,r=-0.291）。结论乳腺癌新辅助化疗前后ADC的变化值可以反映肿瘤细胞增殖活性的变化趋势,为新辅助化疗的疗效评估提供一定帮助。
Objective To study the correlation between ADC value and Ki-67 expression of breast cancer before and after neoadjuvant chemotherapy（ NAC）. Methods Fifty-four cases with breast cancer who were received NAC were included in this study. All patients were performed DWI scan before and after NAC,and then Ki-67 was detected in the pathological tissues. The ADC values and Ki-67 expression of breast cancer before and after NAC were compared. And relationship between ADCpre and Ki-67 pre,ADCpost and Ki-67 post,△ADC and △Ki-67,△ADC% and △Ki-67% were analyzed. Results The value of ADC in breast cancer increased after NAC（ P = 0. 000）,and expression of Ki-67 was decreased（ P = 0. 007）. No correlation was observed between ADCpre and Ki-67 pre（ P = 0. 862）,ADCpost and Ki-67 post（ P = 0. 0292）,△ADC% and △Ki-67%（ P = 0. 562）. However,only △ADC was significantly correlated with △Ki-67（ P = 0. 033,r =-0. 291）. Conclusion The change of ADC during NAC may reflect the change of proliferation of tumor cell,and that would be helpful for assessing the effect of NAC.
作者
罗宁斌
苏丹柯
黄向阳
金观桥
刘丽东
赵阳
LUO Ningbin;SU Danke;HUANG Xiangyang(Centre of Imaging Diagnosis,Affiliated Tumor Hospital of Guangxi Medical University,Nanning,Guangxi Province 530021,P.R.China)
出处
《临床放射学杂志》
CSCD
北大核心
2018年第6期922-925,共4页
Journal of Clinical Radiology
基金
广西科学研究与技术开发计划项目(编号:桂科攻14124004-1-11)
广西壮族自治区卫生厅自筹经费科研课题项目(编号:Z2013418)
关键词
乳腺癌
新辅助化疗
表观扩散系数
KI-67
Breast cancer
Neoadjuvant chemotherapy
Apparent diffusion coefficient
Ki-67
