摘要
目的:研究乳腺癌病灶及血清中HMGA1含量与肿瘤病理特征的相关性。方法:选择2014年8月~2017年10月期间在绵阳市中心医院手术治疗的乳腺癌患者及乳腺良性肿瘤患者,分别作为研究的恶性组和对照组;采集血清并测定HMGA1的含量,采集乳腺癌病灶及乳腺良性肿瘤病灶并测定HMGA1的含量及增殖基因、侵袭基因的表达量。结果:恶性组患者乳腺癌病灶内HMGA1的含量以及血清中HMGA1的含量均显著高于对照组且乳腺癌病灶内HMGA1的含量与血清中HMGA1的含量呈正相关;恶性组患者乳腺癌病灶内CCN5、MMRN2、TCEAL7的mRNA表达量显著低于对照组患者乳腺肿瘤病灶,HPK1、Ki67、Sema4D、RhoA、Gab2、ARK5、SGK3、MMP9的mRNA表达量显著高于对照组患者乳腺肿瘤病灶;高HMGA1含量的恶性组患者乳腺癌病灶内CCN5、MMRN2、TCEAL7的mRNA表达量显著低于低HMGA1含量的恶性组患者,HPK1、Ki67、Sema4D、RhoA、Gab2、ARK5、SGK3、MMP9的mRNA表达量显著高于低HMGA1含量的恶性组患者。结论:乳腺癌病灶及血清中HMGA1的含量异常升高;异常升高的HMGA1能够对肿瘤增殖及侵袭的病理特征做出评估。
Objective：To study the correlation of serum HMGA1 levels in breast cancer lesion and serum with the pathological features of tumor.Methods：The patients with breast cancer and those with benign breast tumor who were treated in Mianyang Central Hospital between August 2014 and October 2017 were selected as the malignant group and the benign group of the study respectively;serum was collected to determine HMGA1 level,and breast cancer lesions and benign tumor breast tumor lesions were collected to determine the level of HMGA1 as well as the expression of proliferation genes and invasion genes.Results：HMGA1 level in breast cancer lesion and HMGA1 level in serum of malignant group were significantly higher than those of control group,and HMGA1 level in breast cancer lesion was positively correlated with HMGA1 level in serum;CCN5,MMRN2,TCEAL7 mRNA expression in breast cancer lesions of malignant group were significantly lower than those in breast tumor lesions of benign group,whereas HPK1 and Ki67,Sema4 D,RhoA,Gab2,ARK5,SGK3 and MMP9 mRNA expression were significantly higher than those in breast tumor lesions of benign group;CCN5,MMRN2,TCEAL7 mRNA expression in breast cancer lesions of malignant group of patients with high HMGA1 level were significantly lower than those of malignant group of patients with low HMGA1 level,whereas HPK1 and Ki67,Sema4 D,RhoA,Gab2,ARK5,SGK3 and MMP9 mRNA expression were significantly higher than those of malignant group of patients with low HMGA1 level.Conclusion：HMGA1 levels abnormally increase in breast cancer lesion and serum;the abnormally elevated HMGA1 can assess the pathological features of tumor proliferation and invasion.
作者
赵丽娟
徐卫云
张晓红
张靖
张珍
唐卓葳
龙丽
ZHAO Li-juan;XU Wei-yun;ZHANG Xiao-hong;ZHANG Jing;ZHANG Zhen;TANG Zhuo-wei;LONG Li(Department of Breast Surgery,Mianyang Central Hospital in Sichuan Province,Mianyang,Sichuan Province,621000,China)
出处
《海南医学院学报》
CAS
2018年第10期1034-1037,共4页
Journal of Hainan Medical University
基金
绵阳市卫生局项目(201401)~~
关键词
乳腺癌
高迁移率族蛋白A1
增殖
侵袭
breast cancer
high mobility group protein A1
proliferation
invasion
