摘要
目的探讨早产儿凝血功能及其在输注新鲜冰冻血浆后相关指标的变化情况。方法随机选取71例住院早产患儿,统计分析凝血酶原时间(PT)、国际标准化比值(INR)、活化部分凝血酶原时间(APTT)、纤维蛋白原(Fbg)、凝血酶时间(TT)及D-二聚体(DD)范围,对其中36例实施输血治疗的早产儿分析其输注新鲜冰冻血浆前后凝血指标的变化。结果 71例早产儿凝血指标的范围分别为PT(16.34±3.49)s、INR 1.46±0.31、APTT(78.20±20.56)s、Fbg(1.78±0.91)g/L、TT(20.24±3.06)s、DD(5.79±10.28)mg/L,其中实施输血治疗的36例早产儿在输注新鲜冰冻血浆前后PT、INR、APTT、Fbg、DD的差异有统计学意义(P<0.05),表现为PT、APTT缩短,INR、DD降低,Fbg升高。结论早产儿凝血功能检测指标的参考范围明显异于成人,输注新鲜冰冻血浆可有效改善早产儿凝血功能。
Objective To evaluate the function of coagulation and changes of coagulation markers in the preterm infants following fresh frozen plasma transfusion. Methods Prothrombin time （PT） , international normalized ratio （INR） , activated partial thrombin time （APTT） , fibrinogen （Fbg） , thrombin time （TT） , and d-dimer （DD） were examined in 71 preterm newborns and the coagulation markers were detected in 36 preterm infants who received treatments of fresh frozen plasma transfusions. Results The range of coagulation parameters were PT （16.34±3.49） s, INR 1.46±0.31, APTT （78.20±20.56） s, Fbg （1.78±0.91） g/L, TT （20.24±3.06） s, and DD （5.79±10.28） mg/L, respectively, in 71 preterm infants. The PT, INR, APTT, Fbg and DD were found to be statistically different in 36 cases of plasma transfusions （P〈0.05） , characterized by shortened PT and APTT, decreased INR and DD, and increased Fbg. Conclusion The reference ranges of coagulation-associated markers may differ between the preterm newborns and adults. Transfusion of fresh frozen plasma may help improve the coagulation function of the preterm infants.
作者
梁晓浏
林正明
江建锋
杨园园
王圆圆
缪燕霞
LIANG Xiao-liu;LIN Zheng-min;JIANG Jian-teng(Department of Blood Transfusion,the First People＇s Hospital of Hefei,Hefei 230061)
出处
《临床输血与检验》
CAS
2018年第4期374-377,共4页
Journal of Clinical Transfusion and Laboratory Medicine
关键词
早产儿
凝血功能
输血
新鲜冰冻血浆
Preterm infants
Coagulation function
Transfusion
Fresh frozen plasma
