摘要
目的分析血栓弹力图与急性脑梗死患者血小板聚集功能的关系。方法选取2016年5月至2017年5月该院收治的急性脑梗死患者100例作为观察组,同期接受体检的健康人100例作为对照组。两组均进行血栓弹力图检测、血小板凝聚功能检测及常规凝血功能检测。应用Preason相关性分析血栓弹力图与急性脑梗死患者血小板聚集功能、凝血功能的相关性。结果观察组患者的凝血反应时间(R)、血细胞凝聚块形成时间(K)水平分别为(6.0±1.8)min、(1.1±0.3)min,均显著低于对照组的(6.8±2.2)min、(2.2±0.5)min(P<0.05)。观察组患者血栓最大弹力度(MA)、血小板聚集率为(69.4±5.0)mm、(71.9±11.2)%,显著高于对照组的(60.1±4.6)mm、(55.7±9.2)%(P<0.05)。观察组患者D-二聚体(DD)以及血浆纤维蛋白原(FIB)水平分别为(0.4±0.2)mg/L、(4.5±0.7)g/L,均显著高于对照组的(0.2±0.1)mg/L、(2.7±0.8)g/L(P<0.05)。Preason相关性分析显示:R、K与急性脑梗死患者血小板聚集率、DD以及FIB均呈负相关(r分别为-0.512、-0.557、-0.497、-0.528、-0.544、-0.567,均P<0.05),而MA与急性脑梗死患者血小板聚集率、DD以及FIB均呈正相关(r分别为0.602、0.592、0.623,均P<0.05)。结论血栓弹力图各项参数与急性脑梗死患者的血小板凝聚功能以及凝血功能存在明显相关性,临床工作中采用血栓弹力图检查有利于对患者病情的评估,从而有效指导临床治疗。
Objective To study the relationship between thrombocytopenia and platelet aggregation function in patients with acute cerebral infarction.Methods Selected 100 patients with acute cerebral infarction received from our hospital from May 2016 to May 2017 as observation group,and 100 healthy patients as control group.were tested for the blood elasticity,platelet aggregation function and routine coagulation function test.Correlation between Preason and platelet aggregation function and coagulation function in patients with acute cerebral infarction was analyzed by correlation analysis.Results The observation group of patients with R,K levels（6.0±1.8）min,（1.1±0.3）min,were significantly lower than in the control group（6.8±2.2）min and（2.2±0.5）min（P〈0.05）.The MA、platelet aggregation rate in the observation group was（69.4±5.0）mm、（71.9±11.2）%,significantly higher than the control group（60.1±4.6）mm、（55.7±9.2）%（P〈0.05）.The levels of DD and FIB in the observation group were（0.4±0.2）mg/L,（4.5±0.7）g/L,both significantly higher than that in the control group（0.2±0.01）mg/L,（2.7±0.8）g/L,and the differences were statistically significant（all P〈0.05）.The Preason correlation analysis available：R,K and platelet aggregation in patients with acute cerebral infarction rate were negatively related,DD and FIB,MA and rate of platelet aggregation in patients with acute cerebral infarction,DD and FIB were positively correlated relationship（all P〈0.05）.Conclusion Thrombosis elastic parameters and platelet aggregation function in patients with acute cerebral infarction and obvious correlation,blood coagulation function in clinical work by thrombus elastic graph examination is helpful for the evaluation of the patient condition,so as to effectively guide the clinical treatment.
作者
林就孟
韦赐秋
LIN Jiumeng;WEI Ciqiu(Department of Blood Transfusion.People＇s Hospital of Guigang City ,Guigang , Guangxi 537100, China)
出处
《国际检验医学杂志》
CAS
2018年第9期1080-1082,1086,共4页
International Journal of Laboratory Medicine
基金
广西壮族自治区卫生与计划生育委员会课题(Z2015315)
