摘要
目的探讨奥氮平联合氟西汀治疗抑郁症的临床效果和不良反应。方法方便选取2015年3月—2017年3月该院收治的94例抑郁症患者,随机分为对照组与实验组,每组47例。对照组给予氟西汀单药治疗,实验组在此基础上联用奥氮平。观察两组治疗前后HAMD评分与HAMA评分以及不良反应发生率。结果实验组治疗后2、4、8周的HAMD评分分别为(26.40±3.79)分、(21.51±3.22)分、(10.53±3.19)分以及HAMA评分(19.33±4.16)分、(15.29±2.68)分、(9.11±2.35)分均优于同期对照组,两组差异有统计学意义(t=4.012、7.234、11.628;3.988、7.014、10.234,P<0.05);实验组药物不良反应发生率为10.6%,明显低于对照组(χ~2=4.624,P<0.05)。结论奥氮平联合氟西汀治疗抑郁症效果满意,安全性高,值得推广和应用。
Objective This paper tries to investigate the clinical effect of olanzapine combined with fluoxetine in the treatment of depression and its adverse reactions. Methods 94 patients with depression from March 2015 to March 2017 were convenient selected and divided into control group and experimental group, each group of 47 cases. The two groups were given the treatment of fluoxetine monotherapy, the experimental group was given olanzapine on this basis. The HAMD score,HAMA score and the incidence of adverse reactions were observed before and after treatment in the two groups. Results The HAMD scores at the 2 nd, 4 th and 8 th weeks after treatment in the experimental group were（26.40±3.79）points,（21.51±3.22）points,（10.53 ±3.19） points, and HAMA scores（19.33 ±4.16）points,（15.29 ±2.68）points,（9.11 ±2.35）points respectively were better than the control group at the same time. There was a statistically significant difference between the two groups（t=4.012,7.234,11.628;3.988,7.014,10.234, P〈0.05）. The incidence of adverse drug reactions in the experimental group was10.6%, significantly lower than the control group（χ2=4.624, P〈0.05）. Conclusion Olanzapine combined with fluoxetine in the treatment of depression with satisfactory effect, high safety, it is worthy of promotion and application.
作者
梁守芳
袁锋
LIANG Shou-fang;YUAN Feng(Laoqu People＇s Hospital of Haifeng,Haifeng,Guangdong Province,516411 China)
出处
《中外医疗》
2018年第15期117-119,共3页
China & Foreign Medical Treatment
关键词
抑郁症
氟西汀
奥氮平
疗效
不良反应
Depression
Fluoxetine
Olanzapine
Efficacy
Adverse reaction
