摘要
目的观察小剂量奥氮平联合氟西汀治疗重度抑郁症的疗效及安全性。方法选取2015年2月-2017年1月在医院进行诊治的重度抑郁症患者96例,将其随机分成研究组与对照组,每组48例。研究组给予小剂量奥氮平联合氟西汀治疗,对照组给予氟西汀治疗,比较2组患者的治疗效果及不良反应。结果研究组总有效率为95.83%高于对照组的79.17%,不良反应发生率为4.17%低于对照组的14.58%,差异均有统计学意义(P<0.05)。结论小剂量奥氮平联合氟西汀治疗重度抑郁症具有显著的效果,且安全性也较高,临床应用推广价值高。
Objective To study the efficacy and safety of low-dose olanzapine combined with fluoxetine in treatment of severe depression.Methods 96 patients with severe depression were selected from February 2015 to January 2017 in the hospital.They were randomly divided into study group and control group,48 patients in each group.Study group received lowdose olanzapine combined with fluoxetine treatment,control group was treated with fluoxetine.Compared the therapeutic effect and treatment safety of two groups.Results The total effective rate in study group was 95.83% higher than 79.17% in control group,The incidence of adverse reactions in study group was 4.17% lower than 14.58% of control group,the differences were statistically significant（P〈0.05）.Conclusion The application of low-dose olanzapine combined with fluoxetine in treatment of patients with severe depression has significant clinical effect,can significantly improve the treatment efficiency,and the safety is high,the clinical application value of high.
出处
《临床合理用药杂志》
2017年第22期17-18,共2页
Chinese Journal of Clinical Rational Drug Use
关键词
抑郁症
重度
氟西汀
奥氮平
临床疗效
安全性
Depression
severe
Fluoxetine
Olanzapine
Clinical efficacy
Safety
