摘要
目的研究小剂量米索前列醇和缩宫素用于足月胎膜早破引产的临床疗效。方法选取2015年3月~2017年10月我院收治的符合纳入标准的220例足月胎膜早破产妇作为研究对象,根据引产方法将其分为观察组与对照组,每组各110例。观察组患者给予小剂量米索前列醇(25μg)治疗,对照组患者给予缩宫素治疗。比较两组患者的引产成功率、用药至临产时间、用药至分娩时间、总产程、产后出血量及羊水污染、胎儿窘迫发生率等。结果观察组与对照组患者的引产成功率分别为88.18%与76.36%,观察组患者的引产成功率显著高于对照组,差异有统计学意义(P<0.05)。观察组患者的用药至临产时间为(6.7±1.4)h,用药至分娩时间为(11.3±1.6)h,总产程为(6.0±1.3)h;对照组患者的用药至临产时间为(8.9±1.1)h,用药至分娩时间为(17.1±1.2)h,总产程为(8.3±1.4)h。观察组患者的用药至临产时间、用药至分娩时间及总产程均显著短于对照组,差异有统计学意义(P<0.05)。观察组患者的羊水污染率(7.27%)、胎儿窘迫发生率(8.18%)显著低于对照组(26.35%、19.10%),差异有统计学意义(P<0.05)。观察组患者的产后出血量[(125.3±74.2)ml]显著少于对照组[(159.2±52.1)ml],差异有统计学意义(P<0.05)。结论对于足月胎膜早破产妇使用小剂量米索前列醇可获得比缩宫素更为显著的效果,引产成功率更高,可以显著缩短产程,减少胎儿宫内窘迫和羊水污染率,具有显著的临床应用价值。
Objective To compare and study the clinical efficacy of low-dose Misoprostol and Oxytocin for the induced labor due to premature rupture of membranes in full-term infants. Methods A total of 220 pregnant women with fullterm premature rupture of membranes who met the inclusion criteria treated in our hospital from March 2015 to October 2017 were selected as objects. They were divided into the observation group and the control group according to the induction method, with 110 cases in each group. Patients in the observation group were given a small dose of Misoprostol（25 μg） for treatment, and the Oxytocin was administered to the patients in the control group. The success rate of induction of labor, time from drug use to labor, time from drug use to delivery, total labor, postpartum hemorrhage and the incidence of amniotic fluid contamination and fetal distress of patients in two groups were compared. Results The success rate of induced labor in the observation group and the control group was 88.18% and 76.36% respectively, the success rate of induced labor in the observation group was significantly higher than that in the control group, and the difference was statistically significant（P〈0.05）. The time from drug use to labour of the observation group was（6.7±1.4）h, the time from drug use to delivery was（11.3±1.6） h and the total labor duration was（6.0±1.3） h; the time from drug use to delivery of the control group was（8.9±1.1） h, the time from drug use to delivery was（17.1±1.2） h and the total labor duration was（8.3±1.4） h. The observation group was significantly shorter than the control group and the differences were statistically significant（P〈0.05）. The amniotic fluid contamination rate（7.27%） and the fetal distress rate（8.18%）in the observation group were significantly lower than those in the control group（26.35%, 19.10%）, the differences were statistically significant（P〈0.05）. The amount of postpartum hemorrhage of the observation group（[125.3
作者
姚璇
YA(Department of Gynecology and Obstetrics,Haimen Hospital of Traditional Chinese Medicine,Jiangsu Province,Haimen 226100,China)
出处
《中国当代医药》
2018年第21期105-107,共3页
China Modern Medicine
关键词
足月胎膜早破
引产
米索前列醇
缩宫素
Premature rupture of membranes in Full-term infants
Induced labour
Misoprostol
Oxytoein
