摘要
孤儿核受体亚家族6成员1(nuclear receptor subfamily 6 group member1,Nr6a1)是激活配体转录因子的核受体超家族成员,也称为生殖细胞核因子(germ cell nuclear factor,GCNF)或视黄酸受体相关睾丸相关核受体(retinoic acid receptor-related testis-associated receptor,RTR)。作为转录因子,Nr6a1通过与靶基因启动子区的DR0元件(TCAAGGTCA)结合发挥转录抑制作用。Nr6a1主要高表达于成熟的生殖细胞、分化阶段的胚胎干细胞以及畸胎瘤等生殖细胞肿瘤中,具有一定的时空表达特异性和组织表达特异性。目前已鉴定了一批Nr6a1的上、下游调控分子,包括miR-181a、let7、Oct4、PPARδ等,通过基因间的互作,Nr6a1在细胞分化、发育、代谢等生物学过程中发挥重要调节作用。
Nuclear receptor subfanfily 6 group menlberl （ Nr6al ） is an active ligand transcription factor menlber of the nuclear receptor supeffanfily, also known as germ cell nuclear factor （GCNF） or retinoie acid receptor-related testis-as- sociated receptor （RTR）. As a transcription factor, Nr6al play-s a role of transcriptional inhibition by binding to the DR0 element （TCAAGGTCA） in the target gene promoter region. Nr6al is mainly expressed in mature germ cells, dif- ferentiated embryonic stem cells and germ cell tumors such as teratoma, which suggested that the expression profile of Nr6al is spatio-temporal specificity and tissue specificity. To date, a number of upstream or downstream of Nr6al regulato- ry molecules including miR-181a, let7, Oct4, PPARδ have been identified. Through the interactions with these genes, Nr6al play-s an important regulating role in biological processes of development, cell differentiation and metabolism.
作者
刘晓雯
刘华伟
王伟龙
李丹
LIU Xiaowen;LIU Huawei;WANG Weilong;LI Dan(College of Biology,Hunan University,Changsha 410082,Hunan,China)
出处
《激光生物学报》
CAS
2018年第3期199-204,217,共7页
Acta Laser Biology Sinica
基金
国家自然科学基金资助项目(81571494)
关键词
Nr6a1
DR0元件
转录抑制
分化
发育
Nr6al
DRO element
transcriptional repression
differentiation
development
