摘要
目的分析诺如病毒感染引起急性胃肠炎的流行病学及临床特点。方法收集分析本院2016年1-12月因诺如病毒性急性胃肠炎患者1 376例的临床资料,使用Real time RT-PCR检测患者标本中诺如病毒核酸及分型,用SPSS22.0软件进行统计分析。结果 1 376例诺如病毒急性胃肠炎患者中,男性734例,女性642例;检测出诺如病毒阳性1 026例,检出率为74.56%,GⅠ型诺如病毒166例(占16.18%),GⅡ型诺如病毒感染860例(占83.82%)。诺如病毒急性胃肠炎患者每天呕吐次数、腹泻次数和发热温度差异无统计学意义;12岁以下患者呕吐发生率均超过98%,随着年龄增长,呕吐发生率越来越低,不同年龄组相比差异有统计学意义(χ2=8.023,P=0.0455)。>18岁年龄组腹泻的发生率最高,为67.43%,年龄越小腹泻的发生率越低,不同年龄组腹泻的发生率差异有统计学意义(χ2=100.042,P<0.01);GⅡ型发热的发生率高于GⅠ基因型,差异有统计学意义(χ2=9.28,P=0.0023)。结论 12岁以下儿童易发生诺如病毒感染性急性胃肠炎;呕吐、腹泻发生率与患者年龄相关;GⅡ型患者比GⅠ型患者有更高的发热症状。
Objective To analyze the epidemiological and clinical features of acute gastroenteritis caused by norovirus infections to provide a scientific basis for prevention of those infections. Methods Clinical data were collected on 1 376 patients with acute gastroenteritis due to a norovirus infection who were seen at this Hospital from January 2016 to December 2016.Real-time RT-PCR was used to detect norovirus nucleic acids in patient samples and to type norovirus.All data were analyzed using the software SPSS22.0. Results Of 1 376 patients,1 026 tested positive for norovirus at a rate of 74.56%.One hundred and sixty-six patients（16.18%）were infected with genogroup I（G I）,and 860（83.82%）were infected with genogroup II（GII）norovirus.Patients with acute gastroenteritis due to a norovirus infection did not differ significantly in terms of the daily frequency of vomiting and diarrhea or in body temperature indicating a fever.Over98% of patients under the age of 12 patients vomited.Vomiting was less prevalent in older patients,and the incidence of vomiting differed significantly among different age groups（χ^2=8.023,P=0.0455）.Diarrhea was most prevalent（67.43%）in patients over the age of 18.Diarrhea was less prevalent in older patients,and the incidence of diarrhea differed significantly among different age groups（χ^2=100.042,P〈0.01）.A fever was more prevalent in patients infected with GII norovirus than in patients infected with GI norovirus.The prevalence of a fever differed significantly for norovirus genogroups（χ^2=9.28,P=0.0023）. Conclusion Acute gastroenteritis due to a norovirus infection often developed in children under 12 years of age.The incidence of vomiting and diarrhea is related to age.Patients infected with GII norovirus developed a fever more often than those infected with GI norovirus.
作者
轩妍
韦伟
张薇
黄晓燕
XUAN Yan;WEI Wei;ZHANG Wei;HUANG Xiao-yan(Neonatology Department,The Maternal and Child Health Hospital of Hainan Province,Haikou 570000,Chin)
出处
《中国病原生物学杂志》
CSCD
北大核心
2018年第6期637-640,共4页
Journal of Pathogen Biology
关键词
诺如病毒
急性胃肠炎
感染
临床特征
Norrovirus
acute gastroenteritis
infection
clinical characteristics
