摘要
目的了解药品不良反应(ADR)发生的规律和特点,为临床合理、安全用药提供参考。方法收集医院2016年上报国家ADR监测中心的有效ADR报告227例,分析给药途径、涉及药品、ADR累及器官和(或)系统及临床表现。结果静脉滴注是引起ADR发生的主要给药途径;抗菌药物及中成药是引起ADR的高发药物,其余依次为抗结核药物、抗肿瘤药物等;ADR累及的器官和(或)系统中皮肤及其附件损害占41.18%,消化系统占10.89%;左氧氟沙星、哌拉西林/三唑巴坦钠、银杏叶注射液等所致ADR较多。结论临床应加强ADR的监测,重点监测严重的ADR,根据ADR发生的规律和特点合理用药,减少或避免ADR的发生。
Objective To study the characteristics and regularity of adverse drug reactions（ ADR） in a hospital,in order to provide reference for safe and rational drug use in the clinic. Methods 227 cases of ADR reported by the hospital to the national ADR monitoring center from 2016 were analyzed retrospectively in respects of the route of administration,related drug categories and ADR involved organs and（ or） systems and clinical manifestations. Results Intravenous infusion was the main route of administration that induced ADR; Antibacterial drugs and proprietary Chinese medicines were high-risk drugs that cause ADR,followed by anti-TB drugs,anti-tumor drugs; From the organ or system involved in ADR,the skin and its accessory lesions was 41. 18%,and the digestive system accounted was 10. 89%; Levofloxacin,piperacillin/tazobactam sodium and ginkgo biloba injection caused more ADR. Conclusion The clinic should strengthen the ADR monitoring,with emphasis on monitoring severe ADRs,according to the regularity and characteristics of ADR occurred,rational use of drugs to reduce or avoid the occurrence of ADR.
作者
陈康娜
余田
CHEN Kangna;YU Tian.(The Fifth Affiliated Hospital of Sun Yat-sen University, Guangdong Province, Zhuhai , 519000 , China)
出处
《临床合理用药杂志》
2018年第19期17-18,20,共3页
Chinese Journal of Clinical Rational Drug Use
关键词
药品不良反应
分析
合理用药
Adverse drug reactions
Analysis
Rational drug use
