摘要
前列腺癌(prostate cancer,PCa)发病率高,根治性治疗后,复发病灶的早期诊断对患者的预后至关重要。前列腺特异性膜抗原(prostate specific membrane antigen,PSMA)是一种在PCa中高表达的跨膜糖蛋白,利用核素^(68)Ga标记其小分子抑制剂作为显像剂,进行PET/CT显像,可以得到反映PCa病灶在体内分布的影像。欧美很多国家已经将^(68)Ga-PSMA PET/CT应用于寻找PCa患者复发病灶,并取得了很好的效果,该技术在我国还处于起步阶段。本文综述了多个有关^(68)Ga-PSMA PET/CT在前列腺癌复发中的研究进展,旨在提高我们对该项新技术的认识水平。
The morbidity of prostate cancer （PCa） is high. Early diagnosis of recurrence after primary treatment is very important for the prognosis. Prostate specific membrane antigen （PSMA） is a transmembrane glycoprotein, with high expression in PCa. Small molecule inhibitors of the PSMA is labeled by 68Ga（68Ga-PSMA）. 68Ga-PSMA is used as imaging agent for PET/CT imaging. 68Ga-PSMA PET/CT can display the distribution of prostate cancer in vivo. Many European and American countries have used 68Ga-PSMA PET/CT to find recurrent lesions in prostate cancer patients and achieved good results. This technology is still in its initial stage in China. This article reviews the research progress of 68Ga-PSMA PET/CT in prostate cancer recurrence, in order to improve the understanding of this new technology in China.
作者
杨立平
李福兴(综述)
李文贵(审校)
YANG Liping;LI Fuxing;LI Wengui(Department of Medical Imaging, Tianjin Baodi Hospital Baodi Clinical College of Tianjin Medical University, Tianjin 301800, China)
出处
《肿瘤防治研究》
CAS
CSCD
2018年第7期505-509,共5页
Cancer Research on Prevention and Treatment
关键词
前列腺肿瘤
复发
68Ga-PSMA
PET/CT
Prostate neoplasms
Recurrence
68Ga-PSMA
Positron-emission tomography/X-ray computedtomography
