摘要
目的探讨基于多次激发回波平面成像(EPI)和二维空间选择激发EPI的快速高分辨扩散加权成像(DWI)对前列腺癌诊断的临床应用价值。资料与方法对6例健康志愿者和13例经穿刺活检证实的前列腺癌患者进行常规和多序列DWI成像,分别测量各DWI序列扫描图像的信噪比(SNR)和表观扩散系数(ADC)值并进行比较分析。另将5例行前列腺癌根治术的整体前列腺病理标本与DWI显示病灶的部位、范围和数量进行对照分析。结果与单次激发EPI相比,多次激发EPI提高了图像的空间分辨率和SNR(P<0.05),二维空间选择激发EPI减少了扫描时间分辨率(P<0.05)。单次激发、多次激发和二维空间选择激发EPI-DWI序列采集的前列腺癌患者的ADC值与健康志愿者的ADC值差异均有统计学意义(P<0.01)。结论基于多次激发和二维空间选择激发EPI的DWI技术可以提高前列腺图像的空间分辨率和SNR,有助于改善前列腺癌的诊断准确性。
Purpose To assess the value of fast high-resolution diffusion-weighted imaging（DWI） based on multi-shot and 2D selective excitation echo planar imaging（EPI） in the diagnosis of prostate cancer.Materials and Methods 6 health volunteers and 13 patients with biopsy confirmed prostate cancer were examined by using the conventional T2WI and multi-sequence DWI.The signal to noise ratio（SNR） estimated from prostate central and peripheral zone and apparent diffusion coefficient（ADC） value estimated from prostate cancer focus and health volunteers were compared among single-shot EPI,multi-shot EPI and 2D selective excitation EPI.In addition,the overall prostate pathological specimens from 5 patients performed radical prostatectomy were compared with the lesion location,ranges and volumes from DWI.Results Compared with single-shot EPI,multi-shot EPI improved the spatial resolution and SNR（P 0.05）,while 2D selective excitation EPI improved the temporal resolution（P0.05） and SNR（P0.05）,which was helpful to improve the diagnosis accuracy for small prostate cancer lesion.There were statistical significant differences of ADC values from single-shot EPI,multi-shot EPI,and 2D selective excitation EPI DWI between patients and healthy volunteers（P 0.01）.Conclusion Prostatic neoplasms;Diffusion magnetic resonance imaging;Diffusion weighted imaging;Echo-planar imaging;Apparent diffusion coefficient
出处
《中国医学影像学杂志》
CSCD
北大核心
2012年第7期485-488,共4页
Chinese Journal of Medical Imaging
基金
2011年深圳市科技计划课题项目(201102039)
2010年深圳市科技计划课题立项(201002140)
